Silk fibroin-based woven endovascular prosthesis with heparin surface modification

Clinical Applications of Biomaterials Original Research
Part of the following topical collections:
  1. Clinical Applications of Biomaterials

Abstract

A novel seamless silk fibroin-based endovascular prosthesis (SFEPs) with bifurcated woven structure and anticoagulant function for the improvement of patency is described. The SFEPs were prepared from silk fibroin (SF) and polyester filaments using an installed weaving machine. The production processing parameters were optimized using orthogonal design methods. The inner surface of SFEPs was modified with polyethylenimine (PEI) and EDC/NHS-activated low-molecular-weight heparin (LMWH) to enhance anticoagulant function. The surface morphology and mechanical properties of the SFEPs were evaluated according to standard protocols. The thickness of modified SFEPs was lower than 0.085 ± 0.004 mm and water permeability was lower than 5.19 ± 0.30 mL/(cm2 × min). The results of mechanical properties showed that the diametral tensile strength and burst strength reached 61.6 ± 1.8 and 23.7 ± 2.2 MPa, respectively. Automatic coagulometer and energy-dispersive X-ray (EDX) confirmed LMWH immobilization on the surface of the SFEPs and the blood compatibility was improved with the heparin modification with PEI polymerization. In conclusion, the new prosthesis has potential applications in the blood vessel repairs where minimal thickness but superior mechanical strength and biocompatibility are important.

Notes

Acknowledgements

This work was supported by the Natural Science Foundation of China (51603140), Natural Science Foundation of Jiangsu Province (BK20150372) and University Science Research Project of Jiangsu Province (16KJB540003). We would like to thank the support of China Postdoctoral Science Foundation, Municipal Science and Technology Project of Nantong and Key Industry Technology Innovation, Science and Technology Project of Suzhou (SYG201638) and Sino-Germany Joint Project (GZ1094).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.National Engineering Laboratory for Modern Silk, College of Textile and Clothing EngineeringSoochow UniversitySuzhouChina
  2. 2.College of TextilesDonghua UniversityShanghaiChina
  3. 3.Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong KongChina
  4. 4.Department of Biomedical EngineeringTufts UniversityMedfordUSA

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