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Synthesis of highly stable and biocompatible gold nanoparticles for use as a new X-ray contrast agent

  • Engineering and Nano-engineering Approaches for Medical Devices
  • Original Research
  • Published:
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Abstract

This work reports a novel reduction procedure for the synthesis of Gum Arabic (GA) capped-gold nanoparticles (AuNPs) in glucosammonium formate as a new ionic liquid. The GA coated AuNPs show good stability in physiological media. The synthesized AuNPs were characterized by UV–Vis spectroscopy, transmission electron microscopy, dynamic light scattering and X-ray diffraction analysis. These stable AuNPs are introduced as a new contrast agent for X-ray Computed Tomography (X-ray CT). These nanoparticles have higher contrasting properties than the commercial contrast agent, Visipaque. The precursors used (Gum Arabic and glucose based-ionic liquid) for synthesis of AuNPs are biocompatible and non-toxic.

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Acknowledgements

The authors wish to express their gratitude to Shiraz University of Medical Sciences, Iran’s National Elites Foundation and Shiraz University Research Council for the support of this work.

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Authors and Affiliations

  1. Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Pooya Iranpour

  2. Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 7194684795, Iran

    Maral Ajamian, Afsaneh Safavi, Nasser Iranpoor & Abdolkarim Abbaspour

  3. Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran

    Sanaz Javanmardi

Authors
  1. Pooya Iranpour
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  2. Maral Ajamian
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  3. Afsaneh Safavi
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  4. Nasser Iranpoor
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  5. Abdolkarim Abbaspour
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  6. Sanaz Javanmardi
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Correspondence to Pooya Iranpour or Afsaneh Safavi.

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Iranpour, P., Ajamian, M., Safavi, A. et al. Synthesis of highly stable and biocompatible gold nanoparticles for use as a new X-ray contrast agent. J Mater Sci: Mater Med 29, 48 (2018). https://doi.org/10.1007/s10856-018-6053-5

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  • DOI: https://doi.org/10.1007/s10856-018-6053-5

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