Wetting ability of biological liquids in presence of metallic nanoparticles

  • L. Torrisi
  • C. Scolaro
  • N. Restuccia
Engineering and Nano-engineering Approaches for Medical Devices Original Research
Part of the following topical collections:
  1. Engineering and Nano-engineering Approaches for Medical Devices


The wetting ability of water and of some biological liquids was measured on different biocompatible surfaces with and without different colloidal metals. Insoluble nanoparticles disperse in biological tissues enhance some properties, such as the interface adhesion between two surfaces, the X-ray contrast of medical images and the absorbed dose during radiotherapy treatments. The introduction of nanoparticles in the liquids generally improves the wetting ability and changes other properties of the solution, due to the different distribution of the adhesion forces, to the nature, morphology and concentration of the added nanoparticles. An investigation on the contact angle of the liquid drops, physiological liquids, including the human blood, placed on different substrates (polymers, ceramics and metals) with and without the use of metallic nanoparticles is presented, evaluated and discussed.


Contact Angle PMMA Liquid Drop Metallic Nanoparticles Ablation Yield 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was performed thanks to the Messina University support given through the project “Research and Mobility” Coordinated by Prof. L. Torrisi n. 74893496.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


  1. 1.
    Huang X, Jain PK, El-Sayed IH, El-Sayed MA. Plasmonic photothermal therapy (PPTT) using gold nanoparticles. Laser Med Sci. 2008; Springer, doi: 10.1007/s10103-007-0470-x.
  2. 2.
    Ghosh P, Han G, De M, Kyu Kim C, Rotello VM. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 2008;60:1307–15.CrossRefGoogle Scholar
  3. 3.
    Hung L, Lee AP. Microfluidic devices for the synthesis of nanoparticles and biomaterials. J Med Biol Eng. 2007;27(1):1–6.Google Scholar
  4. 4.
    Torrisi L. Radiotherapy improvements by using Au nanoparticles. Recent Pat Nanotechnol. 2015;9(2):114–25.Google Scholar
  5. 5.
    Visaria RK, Griffin RJ, Williams BW, Ebbini ES, Paciotti GF, Song CW, Bischof JC. Enhancement of tumor thermal therapy using gold nanoparticle–assisted tumor necrosis factor-α delivery. Mol Carcer Ther. 2006;5(4):797–808.CrossRefGoogle Scholar
  6. 6.
    Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for gram-negative bacteria. J Colloid Interface Sci. 2004;275:177–82.CrossRefGoogle Scholar
  7. 7.
    Foti A, Foti AM, Torrisi L. Auger and Pixe microanalysis of intrauterine devices (IUDs). Clin Exp Obstet Gynecol. 1990;7(3–4):185–94.Google Scholar
  8. 8.
    Scolaro C. Study, physical characterization and wetting ability aspects of biomaterials. PhD Thesis, Doctorate in Physics, University of Messina Publ. (Italy), A.A. 2014.Google Scholar
  9. 9.
    Tzoneva-Velinova R. The wettability of biomaterials determines the protein adsorption and the cellular responses. PhD Thesis, Institute of Chemistry, Universität Potsdam (Germany), 2003.Google Scholar
  10. 10.
    van Wachem PB, Beugeling T, Feijen J, Bantjes A, Detmers JP, van Aken WG. Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities. Biomaterials. 1985;6(6):403–8.Google Scholar
  11. 11.
    Kara ML, Lyndon J. The impact of contact angle on the biocompatibility of biomaterials. Optometry Vision Sci. 2010;87(6):387–99.Google Scholar
  12. 12.
    Xu LC, Siedlecki CA. Effects of surface wettability and contact time on protein adhesion to biomaterial surfaces. Biomaterials. 2007;28(22):3273–83.CrossRefGoogle Scholar
  13. 13.
    Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, De Ronde H, Van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Letter to Nature. 1994;369:64–7.CrossRefGoogle Scholar
  14. 14.
    Torrisi L, Cutroneo M, Ceccio G. Effect of metallic nanoparticles in thin foils for laser ion acceleration. Phys Scripta. 2015;9:015603.CrossRefGoogle Scholar
  15. 15.
    Cutroneo M, Torrisi L, Calcagno L, Torrisi A. Characterization of thin films for TNSA laser irradiation. J Phys Conf Ser. 2014;508(012012):1–7.Google Scholar
  16. 16.
    Torrisi L, Gentile C, Visco AM, Campo N. Wetting modificastions of UHMWPE surfaces induced by ion implantation. Rad Eff and Def in Solids. 2003;158:731–41.CrossRefGoogle Scholar
  17. 17.
    Aksay IA, Hoge CE, Pask JA. Wetting under chemical equilibrium and nonequilibrium conditions. J Phys Chem. 1974;78(12):1178–83.CrossRefGoogle Scholar
  18. 18.
    Atae-Allah C, Cabrerizo-Vılchez M, Gomez-Lopera JF, Holgado-Terriza JA, Roman-Roldan R, Luque-Escamilla PL. Measurement of surface tension and contact angle using entropic edge detection. Meas Sci Technol. 2001;12:288–98.CrossRefGoogle Scholar
  19. 19.
    Pries AR, Neuhaus D, Gaehtgens P. Blood viscosity in tube flow: dependence on diameter and hematocrit. Am J Physiol Heart Circ Physiol. 1992;263(6):H1770–8.Google Scholar
  20. 20.
    Lehtinen KariEJ, Zachariah MichaelR. Effect of coalescence energy release on the temporal shape evolution of nanoparticles. Phys Rev B. 2001;63:205402.CrossRefGoogle Scholar
  21. 21.
    Torrisi L, Scolaro C. Treatment techniques on aluminum to modify the surface wetting properties. Acta Phys Pol A. 2015;128(1):48–53.CrossRefGoogle Scholar
  22. 22.
    Carroll BJ. The accurate measurement of contact angle, phase contact areas, drop volume, and laplace excess pressure in drop-on-fiber systems. J Colloid Interface Sci. 1976;57(3):488–95.CrossRefGoogle Scholar
  23. 23.
    Salata OV. Applications of nanoparticles in biology and medicine. J Nanobiotechnology. 2004;2(3):1–6.Google Scholar
  24. 24.
    Torrisi L, Restuccia N, Cuzzocrea S, Paterniti I, Ielo I, Pergolizzi S, Cutroneo M, Kovacik L. Laser-produced Au nanoparticles as X-ray contrast agents for diagnostic imaging. Gold Bull. 2017;Online First 1-10, doi: 10.1007/s13404-017-0195-y.
  25. 25.
    Ingham B, Lim TH, Dotzler CJ, Henning A, Toney MF, Tilley RD. How nanoparticles coalesce: an in situ study of Au nanoparticle aggregation and grain growth. Chem Mater. 2011;23(14):3312–7.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Dottorato di Ricerca in FisicaUniversità di MessinaS. Agata (ME)Italy

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