Abstract
The introduction of a protective coating layer to highly corrosive magnesium (Mg) has been proposed as one of the common approaches for improved corrosion resistance of Mg-based implants as load-bearing biomedical applications. However, only few studies have focused on the mechanical stability of the coated Mg under practical conditions where significant deformation of the load-bearing implants is induced during the surgical operation or under physiological environments. Therefore, in this study, we developed a dual coating system composed of an interlayer hydroxyapatite (HA) and a top layer poly-l-lactic acid (PLLA) to improve the coating stability under deformation of Mg alloy (WE43) substrate. The HA interlayer was directly formed on the Mg alloy surface, followed by dip-coating of PLLA. As the interlayer, HA improved the adhesion of PLLA by modulating nano- and microscale roughness, in addition to its inherently good bonding strength to Mg. The flexible and deformable top coating PLLA layer mitigated crack propagation in the HA layer under deformation. Thus, the dual coating layer provided good protection to the underlying WE43 from corrosion regardless of deformation. The enhanced corrosion behavior of dual-coated WE43 exhibited better mechanical and biological performance compared to the non-coated or single-coated WE43. Therefore, this dual coating layer on Mg is expected to accelerate Mg-based applications in biomedical devices.
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Chen YJ, Xu ZG, Smith C, Sankar J. Recent advances on the development of magnesium alloys for biodegradable implants. Acta Biomater. 2014;10(11):4561–73.
Farraro KE, Kim KE, Woo SLY, Flowers JR, McCullough MB. Revolutionizing orthopaedic biomaterials: the potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering. J Biomech. 2014;47(9):1979–86.
Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006;27(9):1728–34.
Gu X-N, Zheng Y-F. A review on magnesium alloys as biodegradable materials. Front Mater Sci China. 2010;4(2):111–5. doi:10.1007/s11706-010-0024-1.
Persaud-Sharma D, McGoron A. Biodegradable magnesium alloys: a review of material development and applications. J Biomim Biomater Tissue Eng. 2012;12:25–39. doi:10.4028/www.scientific.net/JBBTE.12.25.
Castellani C, Lindtner RA, Hausbrandt P, Tschegg E, Stanzl-Tschegg SE, Zanoni G, et al. Bone-implant interface strength and osseointegration: biodegradable magnesium alloy versus standard titanium control. Acta Biomater. 2011;7(1):432–40.
Li N, Zheng YF. Novel magnesium alloys developed for biomedical application: a review. J Mater Sci Technol. 2013;29(6):489–502.
Witte F. The history of biodegradable magnesium implants: a review. Acta Biomater. 2010;6(5):1680–92.
Kim SM, Jo JH, Lee SM, Kang MH, Kim HE, Estrin Y, et al. Hydroxyapatite-coated magnesium implants with improved in vitro and in vivo biocorrosion, biocompatibility, and bone response. J Biomed Mater Res A. 2014;102(2):429–41.
Witte F, Fischer J, Nellesen J, Crostack HA, Kaese V, Pisch A, et al. In vitro and in vivo corrosion measurements of magnesium alloys. Biomaterials. 2006;27(7):1013–8.
Atrens A, Liu M, Zainal Abidin NI. Corrosion mechanism applicable to biodegradable magnesium implants. Mater Sci Eng, B. 2010;176(20):1609–36. doi:10.1016/j.mseb.2010.12.017.
Witte F, Kaese V, Haferkamp H, Switzer E, Meyer-Lindenberg A, Wirth CJ, et al. In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials. 2005;26(17):3557–63.
Hornberger H, Virtanen S, Boccaccini AR. Biomedical coatings on magnesium alloys—a review. Acta Biomater. 2012;8(7):2442–55.
Degner J, Singer F, Cordero L, Boccaccini AR, Virtanen S. Electrochemical investigations of magnesium in DMEM with biodegradable polycaprolactone coating as corrosion barrier. Appl Surf Sci. 2013;282:264–70.
Goodman SB, Yao ZY, Keeney M, Yang F. The future of biologic coatings for orthopaedic implants. Biomaterials. 2013;34(13):3174–83.
Wong HM, Yeung KWK, Lam KO, Tam V, Chu PK, Luk KDK, et al. A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants. Biomaterials. 2010;31(8):2084–96.
Bidez MW, Misch CE. Clinical biomechanics in implant dentistry, chap. 5. In: Misch CE, editor. Dental implant prosthetics. 2nd ed. London: Elsevier; 2015. p. 95–106.
Du J, Lee J-H, Jang AT, Gu A, Hossaini-Zadeh M, Prevost R, et al. Biomechanics and strain mapping in bone as related to immediately-loaded dental implants. J Biomech. 2015;48(12):3486–94. doi:10.1016/j.jbiomech.2015.05.014.
Van Oosterwyck H, Duyck J, Vander Sloten J, Van der Perre G, De Cooman M, Lievens S, et al. The influence of bone mechanical properties and implant fixation upon bone loading around oral implants. Clin Oral Implan Res. 1998;9(6):407–18.
Picard L, Phalip P, Fleury E, Ganachaud F. Bonding of silicone rubbers on metal (2) physical chemistry of adhesion. Prog Org Coat. 2015;87:258–66.
Xu LP, Yamamoto A. Characteristics and cytocompatibility of biodegradable polymer film on magnesium by spin coating. Colloid Surface B. 2012;93:67–74.
Collier JP, Surprenant VA, Mayor MB, Wrona M, Jensen RE, Surprenant HP. Loss of hydroxyapatite coating on retrieved total hip components. J Arthroplast. 1993;8:389–93.
Soballe K. Hydroxyapatite ceramic coating for bone implant fixation—mechanical and histological studies in dogs. Acta Orthop Scand. 1993;64:1–58.
Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials. 2006;27(15):2907–15. doi:10.1016/j.biomaterials.2006.01.017.
Hiromoto S, Tomozawa M. Hydroxyapatite coating of AZ31 magnesium alloy by a solution treatment and its corrosion behavior in NaCl solution. Surf Coat Tech. 2011;205(19):4711–9.
Dorozhkin SV. Calcium orthophosphate coatings on magnesium and its biodegradable alloys. Acta Biomater. 2014;10(7):2919–34.
ISO. Implants for surgery. Part 2: Coatings of Hydroxyapatite: Technical Committee ISO/TC 150; 2008.
Jo JH, Kang BG, Shin KS, Kim HE, Hahn BD, Park DS, et al. Hydroxyapatite coating on magnesium with MgF2 interlayer for enhanced corrosion resistance and biocompatibility. J Mater Sci-Mater M. 2011;22(11):2437–47.
Tang H, Xin TZ, Wang FP. Calcium phosphate/titania sol–gel coatings on AZ31 magnesium alloy for biomedical applications. Int J Electrochem Sc. 2013;8(6):8115–25.
Acknowledgments
This work was supported by the Industrial Strategic Technology Development Program (10045329, Development of customized implant with porous structure for bone replacement), funded by the Ministry of Trade, Industry & Energy (MI, Korea).
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Diez, M., Kang, MH., Kim, SM. et al. Hydroxyapatite (HA)/poly-l-lactic acid (PLLA) dual coating on magnesium alloy under deformation for biomedical applications. J Mater Sci: Mater Med 27, 34 (2016). https://doi.org/10.1007/s10856-015-5643-8
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DOI: https://doi.org/10.1007/s10856-015-5643-8