Fabrication, biodegradation behavior and cytotoxicity of Mg-nanodiamond composites for implant application

  • Haibo Gong
  • Babak Anasori
  • Chris R. Dennison
  • Kun Wang
  • E. Caglan Kumbur
  • Randy Strich
  • Jack G. Zhou
Engineering and Nano-engineering Approaches for Medical Devices
Part of the following topical collections:
  1. Engineering and Nano-engineering Approaches for Medical Devices


Mg-based biodegradable implants offer several advantages over their non-degradable or degradable polymeric counterparts used today. However, the low corrosion resistance of Mg in physiologic environment remained as concerns. In this research, nanodiamond (ND) was uniformly dispersed in Mg matrix to induce a protective layer on Mg surface during corrosion. Compared with pure Mg, fabricated Mg-ND nanocomposites had lower corrosion rates, higher corrosion potential, and higher corrosion resistance. Specifically, the corrosion rate of Mg was reduced by 4.5 times by adding 5 wt% of ND particles. Corrosion inhibition effect of ND was thus validated. The chemical interaction and physical adsorption of the ions from simulated body fluid on ND might be the main reason for enhanced corrosion resistance. In vitro biocompatibility test results indicated that Mg-ND nanocomposites were biocompatible since cells growing in contact with corrosion products of Mg-ND maintained high cell viability and healthy morphology. Therefore, Mg-ND nanocomposites with homogenous ND dispersion, enhanced corrosion resistance, and good biocompatibility might be an excellent candidate material for biodegradable implant application.


Corrosion Rate Powder Metallurgy Open Circuit Potential Immersion Test Galvanic Corrosion 
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We gratefully thank the Centralized Research Facility (CRF) of the College of Engineering, Drexel University for providing access to electronic microscopes used in this work. We also would thank the Prof. Donggang Yao for the mentorship, Prof. Richard Chiou for his help in hardness test, Prof. Ying Sun for providing experimental instruments, Dr. Qingwei Zhang and Juan Wang for her help in Mg corrosion study, Xin Yang for his help in SEM, and Ziyan Lin and Edward Gillman for their help in Mg-ND fabrication. We acknowledge support from NSF under the Grant Number CMMI-0927963.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Haibo Gong
    • 1
  • Babak Anasori
    • 2
  • Chris R. Dennison
    • 1
  • Kun Wang
    • 3
  • E. Caglan Kumbur
    • 1
  • Randy Strich
    • 3
  • Jack G. Zhou
    • 1
  1. 1.Department of Mechanical Engineering and MechanicsDrexel UniversityPhiladelphiaUSA
  2. 2.Department of Material EngineeringDrexel UniversityPhiladelphiaUSA
  3. 3.Department of Molecular BiologyRowan UniversityStratfordUSA

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