Mechanical characterization of electrospun gelatin scaffolds cross-linked by glucose
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Nanofibrous gelatin scaffolds were prepared by electrospinning from aqueous acetic acid and cross-linked thermally by glucose. The effect of the amount of glucose used as cross-linking agent on the mechanical properties of gelatin fibres was studied in this paper. The elastic modulus of gelatin fibres cross-linked by glucose was determined by modelling the behaviour of the meshes during tensile test. The model draws connections between the elastic moduli of a fibrous mesh and the fibre material and allows evaluation of elastic modulus of the fibre material. It was found that cross-linking by glucose increases the elastic modulus of gelatin fibres from 0.3 GPa at 0 % glucose content to 1.1 GPa at 15 % glucose content. This makes fibrous gelatin scaffolds cross-linked by glucose a promising material for biomedical applications.
KeywordsElastic Modulus Tensile Test Gelatin Fibre Diameter Fibre Material
This study was financially supported by the European Union through the European Regional Development Fund via projects “Carbon Nanotube Reinforced Electrospun Nano-fibres and Yarns” (3.2.1101.12-0018), “SmaCell” (3.2.1101.12-0017) and Centre of Excellence “Mesosystems: Theory and Applications” (3.2.0101.11-0029) and Estonian Science Foundation Grant IUT2-25.
- 26.Gorgieva S, Kokol V. Collagen- vs. gelatin-based biomaterials and their biocompatibility: review and perspectives. In: Pignatello R, editors. Biomaterials applications for nanomedicine. Rijeka, Croatia: InTech; 2011. p. 17–52.Google Scholar
- 28.Zhan J, Lan P. The review on electrospun gelatin fiber scaffold. J Res Updates Polym Sci. 2012;1:59–71.Google Scholar