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Mechanical characterization of electrospun gelatin scaffolds cross-linked by glucose

  • Biomaterials Synthesis and Characterization
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Abstract

Nanofibrous gelatin scaffolds were prepared by electrospinning from aqueous acetic acid and cross-linked thermally by glucose. The effect of the amount of glucose used as cross-linking agent on the mechanical properties of gelatin fibres was studied in this paper. The elastic modulus of gelatin fibres cross-linked by glucose was determined by modelling the behaviour of the meshes during tensile test. The model draws connections between the elastic moduli of a fibrous mesh and the fibre material and allows evaluation of elastic modulus of the fibre material. It was found that cross-linking by glucose increases the elastic modulus of gelatin fibres from 0.3 GPa at 0 % glucose content to 1.1 GPa at 15 % glucose content. This makes fibrous gelatin scaffolds cross-linked by glucose a promising material for biomedical applications.

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Acknowledgments

This study was financially supported by the European Union through the European Regional Development Fund via projects “Carbon Nanotube Reinforced Electrospun Nano-fibres and Yarns” (3.2.1101.12-0018), “SmaCell” (3.2.1101.12-0017) and Centre of Excellence “Mesosystems: Theory and Applications” (3.2.0101.11-0029) and Estonian Science Foundation Grant IUT2-25.

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Authors and Affiliations

  1. Institute of Physics, University of Tartu, Ravila 14c, 50411, Tartu, Estonia

    Kaido Siimon, Hele Siimon & Martin Järvekülg

  2. Estonian Nanotechnology Competence Center, Tartu, Estonia

    Martin Järvekülg

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  1. Kaido Siimon
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  2. Hele Siimon
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  3. Martin Järvekülg
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Correspondence to Kaido Siimon.

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Siimon, K., Siimon, H. & Järvekülg, M. Mechanical characterization of electrospun gelatin scaffolds cross-linked by glucose. J Mater Sci: Mater Med 26, 37 (2015). https://doi.org/10.1007/s10856-014-5375-1

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  • DOI: https://doi.org/10.1007/s10856-014-5375-1

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