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Highly biocompatible behaviour and slow degradation of a LDH (layered double hydroxide)-coating on implants in the middle ear of rabbits

  • Franziska Duda
  • Marc Kieke
  • Florian Waltz
  • Maria E. Schweinefuß
  • Muhammad Badar
  • Peter Paul Müller
  • Karl-Heinz Esser
  • Thomas Lenarz
  • Peter Behrens
  • Nils Kristian Prenzler
Biocompatibility Studies
Part of the following topical collections:
  1. Biocompatibility Studies

Abstract

Chronic inflammation can irreversibly damage components of the ossicular chain which may lead to sound conduction deafness. The replacement of impaired ossicles with prostheses does not reduce the risk of bacterial infections which may lead to loss of function of the implant and consequently to additional damage of the connected structures such as inner ear, meninges and brain. Therefore, implants that could do both, reconstruct the sound conduction and in addition provide antibacterial protection are of high interest for ear surgery. Layered double hydroxides (LDHs) are promising novel biomaterials that have previously been used as an antibiotic-releasing implant coating to curb bacterial infections in the middle ear. However, animal studies of LDHs are scarce and there exist only few additional data on the biocompatibility and hardly any on the biodegradation of these compounds. In this study, middle ear prostheses were coated with an LDH compound, using suspensions of nanoparticles of an LDH containing Mg and Al as well as carbonate ions. These coatings were characterized and implanted into the middle ear of healthy rabbits for 10 days. Analysis of the explanted prostheses showed only little signs of degradation. A stable health constitution was observed throughout the whole experiment in every animal. The results show that LDH-based implant coatings are biocompatible and dissolve only slowly in the middle ear. They, therefore, appear as promising materials for the construction of controlled drug delivery vehicles.

Keywords

Layered Double Hydroxide Cholesteatoma Drug Release System Bulla Tympanica Coated Prosthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We acknowledge the financial support of the project by the German Research Foundation (DFG) within the Collaborative Research Centre SFB 599 (subprojects D1 and DR1). This work also profited from collaboration in the Cluster of Excellence “Hearing4all”.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Franziska Duda
    • 1
  • Marc Kieke
    • 2
  • Florian Waltz
    • 2
  • Maria E. Schweinefuß
    • 2
  • Muhammad Badar
    • 3
    • 4
  • Peter Paul Müller
    • 3
  • Karl-Heinz Esser
    • 5
  • Thomas Lenarz
    • 1
  • Peter Behrens
    • 2
  • Nils Kristian Prenzler
    • 1
  1. 1.Cluster of Excellence “Hearing4all“, ENT DepartmentHannover Medical SchoolHannoverGermany
  2. 2.Cluster of Excellence “Hearing4all“, Institute for Inorganic ChemistryLeibniz University of HannoverHannoverGermany
  3. 3.Helmholtz Centre for Infection ResearchBraunschweigGermany
  4. 4.Gomal Center of Biochemistry and Biotechnology (GCBB)Gomal UniversityDera Ismail KhanPakistan
  5. 5.Institute of ZoologyUniversity of Veterinary Medicine, Foundation, HannoverHannoverGermany

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