Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 11, pp 2659–2663 | Cite as

A road map for a tissue engineering concept for restoring structure and function after limb loss

  • Dietmar W. Hutmacher


In the 21st century the focus of tissue engineering/regenerative medicine (TE/RM) strategies did change its aim from repair to regeneration [1, 2, 3, 4]. In concert, interdisciplinary teams composed of scientists, engineers and clinicians in the field of TE/RM are now applying the principles of cell transplantation, biomaterial science, and bioengineering to design and fabricate tissue engineered constructs (TEC) that can restore and maintain normal function in diseased and injured tissues [5, 6].

In biology, regeneration is the process of renewal and restoration that makes genomes, cells, tissues, and organs, resilient to natural fluctuations or events that cause trauma and/or injury [7]. The benchmark for tissue engineers working on limb regeneration is the newt. For example, an adult salamander can regenerate a lost arm or leg over and over again; regardless of how many times the part is amputated [8].

Frogs can regenerate a limb during tadpole stages when their limbs...


Tissue Engineering Regenerative Medicine Tissue Interface Limb Loss Opinion Paper 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Science and Engineering Faculty, Regenerative Medicine Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia

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