Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 11, pp 2635–2638 | Cite as

Can we regrow a human arm? A negative perspective from an upper-limb surgeon

  • Antonio Merolli


If we would like to devote time and money to the task of regrowing a human arm, we should feel free to do it, in principle. However, if we recognize a purpose in biomedical research, we must scrutinize this task in the light of a possible clinical application. We will then discover that regrowing a human arm is not only likely to be not possible, but also not required in the clinic. Bionic arms and better reconstructive surgery already provide a different, simpler and easier solution to the loss of a human arm, and should be promoted. Probably, “can we regrow a human arm?” is not the right question. Instead, we should ask, “can we restore the function of a lost human arm?”.


Nerve Growth Factor Human Hand Basal Joint Negative Perspective Morphological Construct 
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  1. 1.
  2. 2.
  3. 3.
    Italian National Insurance Institute for Industrial Accidents Reference Tables 2011.Google Scholar
  4. 4.
  5. 5.
    Haeckel E (1899). Riddle of the Universe at the Close of the 19th Century. Harper and Bros, New York–London 1901, translated by J. McCabe.Google Scholar
  6. 6.
    Tickle C. Developmental cell biology: making digit patterns in the vertebrate limb. Nat Rev Mol Cell Biol. 2006;7:45–53.CrossRefGoogle Scholar
  7. 7.
    Williams PL, Warwick R, editors. “Gray’s anatomy, chapter 2 “Embryology”. 36th ed. London: Churchill Livingstone; 1980.Google Scholar
  8. 8.
    Taniuchi M, Clark HB, Johnson EM Jr. Induction of nerve growth factor receptor in Schwann cells after axotomy. Proc Natl Acad Sci USA. 1986;83(11):4094–8.CrossRefGoogle Scholar
  9. 9.
    Sofroniew MV, Howe CL, Mobley WC. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001;24:1217–81.CrossRefGoogle Scholar
  10. 10.
    Hughes SM, Salinas PC. Control of muscle fibre and motoneuron diversification. Curr Opin Neurobiol. 1999;9(1):54–64.CrossRefGoogle Scholar
  11. 11.
    Carter DR, Wong M. The role of mechanical loading histories in the development of diarthrodial joints. J Orthop Res. 1988;6(6):804–16.CrossRefGoogle Scholar
  12. 12.
    Rosenkilde P, Ussing AP. What mechanisms control neoteny and regulate induced metamorphosis in urodeles? Int J Dev Biol. 1996;40(4):665–73.Google Scholar
  13. 13.
    Ostlie K, Lesjø IM, Franklin RJ, Garfelt B, Skjeldal OH, Magnus P. Prosthesis use in adult acquired major upper-limb amputees: patterns of wear, prosthetic skills and the actual use of prostheses in activities of daily life. Disabil Rehabil Assist Technol. 2012;7(6):479–93.CrossRefGoogle Scholar
  14. 14.
    Jensen SE, Butt Z, Bill A, Baker T, Abecassis MM, Heinemann AW, Cella D, Dumanian GA. Quality of life considerations in upper limb transplantation: review and future directions. J Hand Surg Am. 2012;37(10):2126–35.CrossRefGoogle Scholar
  15. 15.
    Chang J, Mathes DW. Ethical, financial, and policy considerations in hand transplantation. Hand Clin. 2011;27(4):553–60.CrossRefGoogle Scholar
  16. 16.
    Clement RG, Bugler KE, Oliver CW. Bionic prosthetic hands: a review of present technology and future aspirations. Surgeon. 2011;9(6):336–40.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Orthopedic DepartmentThe Catholic University School of MedicineRomeItaly

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