Controlling the kinetic chain length of the crosslinks in photo-polymerized biodegradable networks

  • Janine Jansen
  • Abdul Ghaffar
  • Thomas N. S. van der Horst
  • George Mihov
  • Sjoerd van der Wal
  • Jan Feijen
  • Dirk W. Grijpma


Biodegradable polymer networks were prepared by photo-initiated radical polymerization of methacrylate functionalized poly(d,l-lactide) oligomers. The kinetic chains formed in this radical polymerization are the multifunctional crosslinks of the networks. These chains are carbon–carbon chains that remain after degradation. If their molecular weight is too high these poly(methacrylic acid) chains can not be excreted by the kidneys. The effect of the photo-initiator concentration and the addition of 2-mercaptoethanol as a chain transfer agent on the molecular weight of the kinetic chains was investigated. It was found that both increasing the initiator concentration and adding 2-mercaptoethanol decrease the kinetic chain length. However, the effect of adding 2-mercaptoethanol was much larger. Some network properties such as the glass transition temperature and the swelling ratio in acetone are affected when the kinetic chain length is decreased.


Crosslink Density Methacrylic Acid PMAA Kinetic Chain Urethane Acrylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We acknowledge Tieme Stevens for performing the MALDI-TOF MS measurements. This work was financially supported by DSM.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Janine Jansen
    • 1
  • Abdul Ghaffar
    • 2
    • 3
  • Thomas N. S. van der Horst
    • 1
  • George Mihov
    • 4
  • Sjoerd van der Wal
    • 2
  • Jan Feijen
    • 5
  • Dirk W. Grijpma
    • 1
    • 6
  1. 1.Department of Biomaterials Science and TechnologyFaculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of TwenteEnschedeThe Netherlands
  2. 2.Van’t Hoff Institute for Molecular Sciences, Polymer-Analysis Group, University of AmsterdamAmsterdamThe Netherlands
  3. 3.Department of ChemistryUniversity of Engineering and TechnologyLahorePakistan
  4. 4.DSM AheadGeleenThe Netherlands
  5. 5.Department of Polymer Chemistry and BiomaterialsFaculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of TwenteEnschedeThe Netherlands
  6. 6.Department of Biomedical EngineeringW.J. Kolff Institute, University Medical Center Groningen, University of GroningenGroningenThe Netherlands

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