Controlling the kinetic chain length of the crosslinks in photo-polymerized biodegradable networks
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Biodegradable polymer networks were prepared by photo-initiated radical polymerization of methacrylate functionalized poly(d,l-lactide) oligomers. The kinetic chains formed in this radical polymerization are the multifunctional crosslinks of the networks. These chains are carbon–carbon chains that remain after degradation. If their molecular weight is too high these poly(methacrylic acid) chains can not be excreted by the kidneys. The effect of the photo-initiator concentration and the addition of 2-mercaptoethanol as a chain transfer agent on the molecular weight of the kinetic chains was investigated. It was found that both increasing the initiator concentration and adding 2-mercaptoethanol decrease the kinetic chain length. However, the effect of adding 2-mercaptoethanol was much larger. Some network properties such as the glass transition temperature and the swelling ratio in acetone are affected when the kinetic chain length is decreased.
KeywordsCrosslink Density Methacrylic Acid PMAA Kinetic Chain Urethane Acrylate
We acknowledge Tieme Stevens for performing the MALDI-TOF MS measurements. This work was financially supported by DSM.
- 6.Brenner BM, Hostetter TH, Humes HD. Glomularpermselectivity: barrier function based on discrimination of molecular-size and charge. Am J Physiol. 1978;234:F455–60.Google Scholar
- 10.Ross WM, Martens AC, Vanbekkum DW. Polymethacrylic acid: induction of lymphocytosis and tissue distribution. Cell Tissue Kinet. 1975;8:467–77.Google Scholar
- 13.Peters R, Litvinov VM, Steeman P, Dias AA, Mengerink Y, van Benthem R, de Koster CG, van der Wal S, Schoenmakers P. Characterisation of UV-cured acrylate networks by means of hydrolysis followed by aqueous size-exclusion combined with reversed-phase chromatography. J Chromatogr A. 2007;1156:111–23.CrossRefGoogle Scholar
- 14.Ghaffar A, Verschuren PG, Geenevasen JAJ, Handels T, Berard J, Plum B, Dias AA, Schoenmakers PJ, van der Wal S. Fast in vitro hydrolytic degradation of polyester urethane acrylate biomaterials: structure elucidation, separation and quantification of degradation products. J Chromatogr A. 2011;1218:449–58.CrossRefGoogle Scholar
- 19.Deneke SM. Current topics in cellular regulation. San Diego: Academic Press Inc; 2000.Google Scholar