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Effect of Ca contamination on apatite formation in a Ti metal subjected to NaOH and heat treatments

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Abstract

It has long been known that titanium (Ti) metal bonds to living bone through an apatite layer formed on its surface in the living body after it had previously been subjected to NaOH and heat treatments and as a result had formed sodium titanate on its surface. These treatments were applied to a porous Ti metal layer on a total hip joint and the resultant joint has been in clinical use since 2007. It has been also demonstrated that the apatite formation on the treated Ti metal in the living body also occurred in an acelullar simulated body fluid (SBF) with ion concentrations nearly equal to those of the human blood plasma, and hence bone-bonding ability of the treated Ti metal can be evaluated using SBF in vitro. However, it was recently found that certain Ti metals subjected to the same NaOH and heat treatments display apatite formation in SBF which is decreased with the increasing volume of the NaOH solution used in some cases. This indicates that bone-bonding ability of the treated Ti metal varies with the volume of the NaOH solution used. In the present study, this phenomenon was systematically investigated using commercial NaOH reagents and is considered in terms of the structure and composition of the surface layers of the treated Ti metals. It was found that a larger amount of the calcium contamination in the NaOH reagent is concentrated on the surface of the Ti metal during the NaOH treatment with an increasing volume of the NaOH solution, and that this inhibited apatite formation on the Ti metal in SBF by suppressing Na ion release from the sodium titanate into the surrounding fluid. Even a Ca contamination level of 0.0005 % of the NaOH reagent was sufficient to inhibit apatite formation. On the other hand, another NaOH reagent with a nominal purity of just 97 % did not exhibit any such inhibition, since it contained almost no Ca contamination. This indicates that NaOH reagent must be carefully selected for obtaining reliable bone-bonding implants of Ti metal by the NaOH and heat treatments.

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References

  1. Yan WQ, Nakamura T, Kobayashi M, Kim HM, Miyaji F, Kokubo T. Bonding of chemically treated titanium implants to bone. J Biomed Mater Res. 1997;37:267–75.

    Article  CAS  Google Scholar 

  2. Hacking SA, Tanzer M, Harvey EJ, Krygier JJ, Bobyn JD. Relative contributions of chemistry and topography to the osseointegration of hydroxyapatite coatings. Clin Orthop Relat Res. 2002;405:24–38.

    Article  Google Scholar 

  3. Nishiguchi S, Fujibayashi S, Kim H-M, Kokubo T, Nakamura T. Biology of alkali- and heat-treated titanium implants. J Biomed Mater Res. 2003;67A:26–35.

    Article  CAS  Google Scholar 

  4. Kawanabe K, Ise K, Goto K, Akiyama H, Nakamura T, Kaneuji A, Sugimori T, Matsumoto T. A new cementless total hip arthroplasty with bioactive titanium porous-coating by alkaline and heat treatment: average 4.8-year results. J Biomed Mater Res B. 2008;90:476–81.

    Google Scholar 

  5. Kokubo T, Miyaji F, Kim H-M, Nakamura T. Spontaneous formation of bonelike apatite layer on chemically treated titanium metals. J Am Ceram Soc. 1996;79:1127–9.

    Article  CAS  Google Scholar 

  6. Kim H-M, Miyaji F, Kokubo T, Nakamura T. Preparation of bioactive Ti and alloys via simple chemical surface treatment. J Biomed Mat Res. 1996;32:409–17.

    Article  CAS  Google Scholar 

  7. ISO 23317, Implants for surgery––in vitro evaluation for apatite-forming ability of implant materials; 2007.

  8. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity. Biomaterials. 2006;27:2907–15.

    Article  CAS  Google Scholar 

  9. Tsai C-C, Teng H. Structure features of nanotubes synthesized from NaOH treatment on TiO2 with different post-treatments. Chem Mater. 2006;18:367–73.

    Article  CAS  Google Scholar 

  10. Ou H-H, Lo S-L. Review of titania nanotubes synthesized via the hydrothermal treatment: fabrication, modification, and application. Separ Purific Tech. 2007;58:179–91.

    Article  CAS  Google Scholar 

  11. Margado E Jr, de Abreu MAS, Pravia ORC, Marinkovic BA, Jardim PM, Rizzo FC, Araújo AS. A study on the structure and thermal stability of titanate nanotubes as a function of sodium content. Solid State Sci. 2006;8:888–900.

    Article  Google Scholar 

  12. Sun X, Li Y. Synthesis and characterization of ion-exchangeable titanate nanotubes. Chem Eur J. 2003;9:2229–38.

    Article  CAS  Google Scholar 

  13. Kim H-M, Himeno T, Kawashita M, Lee J-H, Kokubo T, Nakamura T. Surface potential change in bioactive titanium metal during the process of apatite formation in simulated body fluid. J Biomed Mater Res. 2003;67A:1305–9.

    Article  CAS  Google Scholar 

  14. Textor M, Sittig C, Frauchiger V, Tosatti S, Brunette DM. In: Brunette DM, Tengvall P, Textor M, Thomsen P, editors. Properties and biological significance of natural oxide films on titanium and its alloys, in titanium in medicine. Berlin: Springer; 2001. p. 171–230.

    Google Scholar 

  15. Kingely WD, Bowen HK, Uhlmann DR. Introduction to ceramics. 2nd ed. New York: Wiley; 1976. p. 262.

    Google Scholar 

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Correspondence to Takashi Kizuki.

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Kizuki, T., Takadama, H., Matsushita, T. et al. Effect of Ca contamination on apatite formation in a Ti metal subjected to NaOH and heat treatments. J Mater Sci: Mater Med 24, 635–644 (2013). https://doi.org/10.1007/s10856-012-4837-6

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  • DOI: https://doi.org/10.1007/s10856-012-4837-6

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