Characterization and photodynamic activity of a new phthalocyanine nanoparticles

  • Rui Lin
  • Lin Zhou
  • Ke-Long Fang
  • Yun Lin
  • Ao Wang
  • Jia-Hong Zhou
  • Shao-Hua Wei


Nanoparticles of a hydrophobic photosensitizer, tetrakis (3-trifluoromethylphenoxy) zinc phthalocyanine (FPcZn) have been synthesized by using a simple reprecipitation technique. The resulting drug nanoparticles (FPcZn-NP) were spherical, highly monodispersed and stable in aqueous system, without an additional stabilizer. Comparative studies with FPcZn-NP and FPcZn indicated that after the formation of nanoparticles, FPcZn-NP maintained the efficiency of 1O2 generation. Further more, the in vitro studies demonstrated that such nanoparticles can be efficiently taken up by Hela cells, which might be resulted to cell death by light irradiation. These properties could make the FPcZn-NP to be a promising candidate in clinical photodynamic therapy.


HeLa Cell Phthalocyanine Dynamic Light Scattering High Pressure Mercury Lamp Singlet Oxygen Generation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the National Natural Science Foundation of China (20973093 and 20673958) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Rui Lin
    • 1
  • Lin Zhou
    • 1
  • Ke-Long Fang
    • 1
  • Yun Lin
    • 1
  • Ao Wang
    • 1
  • Jia-Hong Zhou
    • 1
    • 2
  • Shao-Hua Wei
    • 1
  1. 1.Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials ScienceNanjing Normal UniversityNanjingPeople’s Republic of China
  2. 2.Analysis Testing CenterNanjing Normal UniversityNanjingPeople’s Republic of China

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