Characterization and photodynamic activity of a new phthalocyanine nanoparticles
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Nanoparticles of a hydrophobic photosensitizer, tetrakis (3-trifluoromethylphenoxy) zinc phthalocyanine (FPcZn) have been synthesized by using a simple reprecipitation technique. The resulting drug nanoparticles (FPcZn-NP) were spherical, highly monodispersed and stable in aqueous system, without an additional stabilizer. Comparative studies with FPcZn-NP and FPcZn indicated that after the formation of nanoparticles, FPcZn-NP maintained the efficiency of 1O2 generation. Further more, the in vitro studies demonstrated that such nanoparticles can be efficiently taken up by Hela cells, which might be resulted to cell death by light irradiation. These properties could make the FPcZn-NP to be a promising candidate in clinical photodynamic therapy.
KeywordsHeLa Cell Phthalocyanine Dynamic Light Scattering High Pressure Mercury Lamp Singlet Oxygen Generation
This work was supported by the National Natural Science Foundation of China (20973093 and 20673958) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).