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Effect of protein concentrations of bovine serum albumin and γ-globulin on the frictional response of a cobalt-chromium femoral head

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Abstract

The study aims to identify the concentration-dependent role of bovine serum albumin (BSA) and γ-globulin in the lubricating ability of a cobalt-chromium femoral head. The frictional coefficients of the cobalt-chromium femoral head decreased with increasing BSA concentrations from 10 to 40 mg/ml and showed statistical differences between any of the BSA concentration groups, except between the 30 and 40 mg/ml concentration groups. In γ-globulin, the frictional coefficients significantly decreased at concentrations of 2.5 and 5.0 mg/ml as compared with the PBS control group, but significant increases were observed at 7.5 and 12.5 mg/ml. These results suggest that the friction of the cobalt-chromium femoral head is dependent on the concentration of both BSA and γ-globulin. However, there is a maximum concentration for BSA to act as an effective boundary lubricant, while the lubricating ability of γ-globulin is most effective in the physiological concentration range within human synovial fluid.

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Acknowledgments

This research was supported by WCU (World Class University) program and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (R33-10155, 2010-0021759).

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Authors and Affiliations

  1. School of Mechanical Engineering & Institute for Skeletal Aging, Pusan National University, Busan, Republic of Korea

    Cong-Truyen Duong, Jae-Hoon Lee, Younho Cho & Seonghun Park

  2. Orthopedic Surgery & Institute for Skeletal Aging, Hallym University, College of Medicine, Chuncheon, Republic of Korea

    Ju-Suk Nam, Hyong-Nyun Kim & Sang-Soo Lee

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  1. Cong-Truyen Duong
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  2. Jae-Hoon Lee
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  3. Younho Cho
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  5. Hyong-Nyun Kim
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  6. Sang-Soo Lee
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  7. Seonghun Park
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Correspondence to Sang-Soo Lee or Seonghun Park.

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Duong, CT., Lee, JH., Cho, Y. et al. Effect of protein concentrations of bovine serum albumin and γ-globulin on the frictional response of a cobalt-chromium femoral head. J Mater Sci: Mater Med 23, 1323–1330 (2012). https://doi.org/10.1007/s10856-012-4603-9

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  • DOI: https://doi.org/10.1007/s10856-012-4603-9

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