Electrospun fibrous scaffold of hydroxyapatite/poly (ε-caprolactone) for bone regeneration

  • Lingli Li
  • Guang Li
  • Jianming Jiang
  • Xiaona Liu
  • Li Luo
  • Kaihui Nan


Development of fibrous scaffold of hydroxyapatite/biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. Hydroxyapatite (HA)/poly (ε-caprolactone) (PCL) fibrous scaffolds were successfully prepared by electrospinning dopes containing HA and PCL in this work. It was found that pre-treating HA with γ-glycioxypropyltrimethoxysilane (A-187) was effective in improving HA dispersion both in solutions and in a PCL matrix. Mechanical properties of the scaffolds were greatly enhanced by the filling of A187-HA. The bioactivity of PCL was remarkably improved by the addition of HA and A187-HA. Fibroblasts and osteoblasts were seeded on scaffolds to evaluate the effect of A-187 on biocompatibility of HA/PCL composites. Based on this study, good dispersion of HA in PCL matrix was granted by pretreatment of HA with A-187 and A187-HA/PCL fibrous scaffolds were obtained by electrospinning. These results demonstrated that the scaffolds may possess improved mechanical performance and good bioactivity due to A187-HA incorporation.


Apatite MG63 Cell Composite Nanofibers Electrospun Fiber Electrospun Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by the programme of Introducing Talents of Discipline to Universities (No. 111-2-04) in Shanghai, the Fund for Key Scientific and Technological Innovation in Zhejiang Province (2011R09039-07) and the scientific research programme of Department of Education in Zhejiang Province for Higher Education (Y201016694).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Lingli Li
    • 1
  • Guang Li
    • 2
  • Jianming Jiang
    • 2
  • Xiaona Liu
    • 1
  • Li Luo
    • 1
  • Kaihui Nan
    • 1
  1. 1.Affiliated Eye HospitalWenzhou Medical CollegeWenzhouPeople’s Republic of China
  2. 2.State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsShanghaiPeople’s Republic of China

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