A new cyclodextrin-grafted viscose loaded with aescin formulations for a cosmeto-textile approach to chronic venous insufficiency

  • G. Cravotto
  • L. Beltramo
  • S. Sapino
  • A. Binello
  • M. E. Carlotti


Cosmeto-textile applications can be used in the treatment of chronic venous insufficiency in legs by means of elastic bandages loaded with natural products which possess flebotonic properties. We have developed an efficient synthetic procedure for the preparation of β-cyclodextrin (β-CD)-grafted viscose by means of a 2-step ultrasound-assisted reaction. The highly grafted fabric bearing bis-urethane bridged β-CD has been characterized by ATR-FTIR and CP-MAS spectra and by an empiric colorimetric method which used phenolphthalein as the CD guest. We have also developed a suitable cosmetic preparation containing natural substances and extracts (aescin, menthol, Centella asiatica and Ginkgo biloba) to recharge the CD-grafted textile. The efficacy of the new cosmeto-textile has been corroborated by in vitro studies of diffusion through membranes, cutaneous permeation and accumulation in porcine skin. Aescin was taken as a reference compound and its concentration in the different compartments was monitored by HPLC analysis. This cost effective cosmeto-textile shows excellent application compliance and is easily recharged and so has the strong base characteristics needed for possible industrial production.


Menthol Skin Permeation Porcine Skin Donor Phase Chronic Venous Insufficiency 
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  1. 1.
    L. Ripoll, C. Bordes, S. Etheve, A. Elaissari, H. Fessi, e-Polymers; 2010, no. 040. ISSN 1618-7229.Google Scholar
  2. 2.
    Nichifor M, Constantin M, Mocanu G, Fundueanu G, Branisteanu D, Costuleanu M, Radu CD. J Mater Sci Mater Med. 2009;20:975. doi: 10.1007/s10856-008-3653-5.CrossRefGoogle Scholar
  3. 3.
    Committee on herbal medicinal products (HMPC - EMEA), List of references for assessment of Aesculus hippocastanum L. Doc. Ref. EMEA/HMPC/225629/2008.Google Scholar
  4. 4.
    U. Siebert, M. Brach, G. Sroczynski, K. Űberla, International Angiology, 21, 305 (2002). INIST-CNRS, Cote INIST : 19982, 35400010791938.0010.Google Scholar
  5. 5.
    Sirtori CR. Pharmacol Res. 2001;44:183. doi: 10.1006/phrs.2001.0847.CrossRefGoogle Scholar
  6. 6.
    Buschmann HJ, Schollmeyer E. J Cosmet Sci. 2002;53:185.Google Scholar
  7. 7.
    Denter U, Bushmann HJ, Schollmeyer E. Textilveredlung. 1991;26:113.Google Scholar
  8. 8.
    Szejtli J. Starch-Starke. 2003;55:191. doi: 10.2002/star.200390050.CrossRefGoogle Scholar
  9. 9.
    A. Bereck. Adva Mater Res 93/94, 1 (2010) doi:10.4028/
  10. 10.
    Denter U, Buschmann H-J, Knittel D, Schollmeyer E. Textilveredlung. 1997;32:33. doi: 10.1023/A:1011892600388.Google Scholar
  11. 11.
    J. Szejtli, B. Zsadon, E. Fenyvesi, O. Horvarth, F. Tudos, US Patent, 4357468 (1982).Google Scholar
  12. 12.
    El Ghoul Y, Blanchemain N, Laurent T, Campagne C, Achari AEl, Roudesli S, Morcellet M, Martel B, Hildebrand HF. Acta Biomater. 2008;4:1392. doi: 10.1016/j.actbio.2008.02.019.CrossRefGoogle Scholar
  13. 13.
    Voncina B, Le Marechal AM. J Appl Polymer Sci. 2005;96:1323. doi: 10.1002/app.21442.CrossRefGoogle Scholar
  14. 14.
    Cravotto G, Boffa L, Genzini L, Garella D. J Clin Pharm Ther. 2010;35:11. doi: 10.1111/j.1365-2710.2009.01096.x.CrossRefGoogle Scholar
  15. 15.
    Cravotto G, Binello A, Baranelli E, Carraro P, Trotta F. Curr Nutr Food Sci. 2006;2:343.CrossRefGoogle Scholar
  16. 16.
    Carlotti ME, Sapino S, Gallarate M, Trotta M, Cavalli R, Ugazio E. J Dispers Sci Technol. 2008;29:1445. doi: org/10.1080/01932690802313543.CrossRefGoogle Scholar
  17. 17.
    Peira E, Carlotti ME, Trotta C, Cavalli R, Trotta M. Int J Pharm. 2008;346:119. doi: 10.1016/j.ijpharm.2007.05.065.CrossRefGoogle Scholar
  18. 18.
    Diembeck W, Beck H, Benech-Kieffer F, Courtellemont P, Dupuis J, Lovell W, Paye M, Spengler J, Steiling W. Food Chem Toxicol. 1999;37:191.CrossRefGoogle Scholar
  19. 19.
    Nelson G. Int J Pharm. 2002;242:55.CrossRefGoogle Scholar
  20. 20.
    Andreaus J, Dalmolin MC, de Oliveira Junior IB, Barcellos IO. Quim Nova. 2010;33:929.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • G. Cravotto
    • 1
  • L. Beltramo
    • 1
  • S. Sapino
    • 1
  • A. Binello
    • 1
  • M. E. Carlotti
    • 1
  1. 1.University of TurinTurinItaly

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