Poly(ε-caprolactone) and poly(d,l-lactic acid-co-glycolic acid) scaffolds used in bone tissue engineering prepared by melt compression–particulate leaching method

  • Samuel H. Barbanti
  • Arnaldo R. SantosJr
  • Cecília A. C. Zavaglia
  • Eliana A. R. Duek


Porous bioresorbable polymers have been widely used as scaffolds in tissue engineering. Most of the bioresorbable scaffolds are aliphatic polyesters and the methods employed to prepare the porous morphology may vary. This work describes and evaluates the in vitro degradation of porous and dense scaffolds of poly(ε-caprolactone) (PCL) and poly(d,l-lactic acid-co-glycolic acid) (50/50) (PLGA50) prepared by particulate leaching-melt compression process. Biological evaluation was carried out using osteoblast cell cultures. The results showed an autocatalytic effect on the dense samples. Osteoblasts presented intermediate adhesion and the cell morphology on the surface of these materials was dispersed, which indicated a good interaction of the cells with the surface and the material.


PLLA Porous Scaffold Salt Particle Average Molar Mass PLGA50 Scaffold 
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This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq) (Grant 141582).


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Samuel H. Barbanti
    • 1
    • 2
  • Arnaldo R. SantosJr
    • 3
  • Cecília A. C. Zavaglia
    • 1
  • Eliana A. R. Duek
    • 1
    • 2
  1. 1.Department of Materials Engineering, Faculty of Mechanical EngineeringState University of Campinas (UNICAMP)CampinasBrazil
  2. 2.Department of Physiological Sciences, Faculty of Biological SciencesPontificial Catholic University of São Paulo (PUCSP)SorocabaBrazil
  3. 3.Natural and Human Sciences CenterFederal University of the ABC (UFABC)Santo AndréBrazil

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