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RETRACTED ARTICLE: Functionalization of titanium based metallic biomaterials for implant applications

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Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

This article was retracted on 08 November 2011

This article was retracted on 08 November 2011

Abstract

Surface immobilization with active functional molecules (AFMs) on a nano-scale is a main field in the current biomaterial research. The functionalization of a vast number of substances and molecules, ranging from inorganic calcium phosphates, peptides and proteins, has been investigated throughout recent decades. However, in vitro and in vivo results are heterogeneous. This may be attributed partially to the limits of the applied immobilization methods. Therefore, this paper highlights the advantages and limitations of the currently applied methods for the biological nano-functionalization of titanium-based biomaterial surfaces. The second part describes a newer immobilization system, using the nanomechanical fixation of at least partially single-stranded nucleic acids (NAs) into an anodic titanium oxide layer as an immobilization principle and their hybridization ability for the functionalization of the surface with active functional molecules conjugated to the respective complementary NA strands.

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  1. Department of Biologic and Material Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA

    Rahul Bhola, Fengyun Su & Catherine E. Krull

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  1. Rahul Bhola
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  2. Fengyun Su
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Correspondence to Rahul Bhola.

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This article has been retracted due to plagiarism.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10856-011-4459-4

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Bhola, R., Su, F. & Krull, C.E. RETRACTED ARTICLE: Functionalization of titanium based metallic biomaterials for implant applications. J Mater Sci: Mater Med 22, 1147–1159 (2011). https://doi.org/10.1007/s10856-011-4305-8

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