An in vitro release study of indomethacin from nanoparticles based on methyl methacrylate/glycidyl methacrylate copolymers
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Indomethacin was coupled onto some macromolecular nanostructures based on methyl methacrylate copolymers with glycidyl methacrylate and tested as a model drug. The polymeric matrices were synthesized by radical emulsion copolymerization with and without the presence of a continuous external magnetic field of 1500 Gs intensity. Mathematical analysis of the release data was performed using Higuchi, Peppas–Korsmeyer equations. NIR chemical imaging (NIR-CI) was used to provide information about the spatial distribution of the components in the studied nanostructures. This opportunity was used to visualize the spatial distribution of bioactive substances (indomethacin) into the polymeric matrix, as well as to evaluate the degree of chemical and/or physical heterogeneity of the bioactive samples. The release rate dependence on the synthesis conditions as well as on the chemical compositions of the tested polymeric systems, it was also evidenced.
KeywordsDrug Release Indomethacin Partial Little Square Polymeric Matrice Sodium Lauryl Sulphate
The authors thank to Prof. Clara Silvestre and Prof. Sossio Cimmino (CNR-Istituto di Chimica e Tecnologia dei Polimeri—Naples Italy) for their support and their many and helpful suggestions regarding SEM microscopy. This research was financially suported by European Social Fund—“Cristofor I. Simionescu” Postdoctoral Fellowship Programme (IDPOSDRU/89/1.5/S/55216), Sectoral Operational Programme Human Resources Development 2007–2013.
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