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A nanoencapsulated hypocrellin A prepared by an improved microemulsion method for photodynamic treatment

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Abstract

A new hypocrellin A (HA) encapsulated silica nanoparticles was prepared by an improved microemulsion method based on the unique character of cetyl trimethyl ammonium bromide (CTAB). Stable aqueous dispersions of the HA-loaded nanoparticles, with the diameter about 50 nm, owned superior photo-stability and singlet oxygen generation ability to free HA. In vitro studies demonstrated the active uptake of HA-doped nanoparticles into the cytosol of HeLa (human cervix epithelioid carcinoma) cells. Significant morphology change and phototoxicity to such impregnated tumor cells was observed upon irradiation with light. Thus, the potential of using this method to prepare silica nanoparticles as drug carriers for photodynamic therapy has been demonstrated.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China (No. 20603018) and the key laboratory of photochemical conversion and optoelectronic materials, TIPC, CAS.

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Authors and Affiliations

  1. Department of Complex Prescription of TCM, China Pharmaceutical University, 211198, Nanjing, People’s Republic of China

    Lin Zhou & Bo-Yang Yu

  2. Xuchang Vocational Technical College, 461000, Xuchang, People’s Republic of China

    Yu-Wei Ning

  3. Jiangsu Key Laboratory Biofunctional Materials, Analysis and Testing Center, Nanjing Normal University, 210097, Nanjing, People’s Republic of China

    Shao-Hua Wei, Yu-Ying Feng, Jia-Hong Zhou & Jian Shen

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  1. Lin Zhou
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  2. Yu-Wei Ning
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  3. Shao-Hua Wei
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  5. Jia-Hong Zhou
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Correspondence to Jia-Hong Zhou or Bo-Yang Yu.

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Zhou, L., Ning, YW., Wei, SH. et al. A nanoencapsulated hypocrellin A prepared by an improved microemulsion method for photodynamic treatment. J Mater Sci: Mater Med 21, 2095–2101 (2010). https://doi.org/10.1007/s10856-010-4067-8

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  • DOI: https://doi.org/10.1007/s10856-010-4067-8

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