A nanoencapsulated hypocrellin A prepared by an improved microemulsion method for photodynamic treatment
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A new hypocrellin A (HA) encapsulated silica nanoparticles was prepared by an improved microemulsion method based on the unique character of cetyl trimethyl ammonium bromide (CTAB). Stable aqueous dispersions of the HA-loaded nanoparticles, with the diameter about 50 nm, owned superior photo-stability and singlet oxygen generation ability to free HA. In vitro studies demonstrated the active uptake of HA-doped nanoparticles into the cytosol of HeLa (human cervix epithelioid carcinoma) cells. Significant morphology change and phototoxicity to such impregnated tumor cells was observed upon irradiation with light. Thus, the potential of using this method to prepare silica nanoparticles as drug carriers for photodynamic therapy has been demonstrated.
KeywordsSinglet Oxygen Silica Nanoparticles Cetyl Trimethyl Ammonium Bromide Cetyl Trimethyl Ammonium Bromide Amino Silane
This research was supported by the National Natural Science Foundation of China (No. 20603018) and the key laboratory of photochemical conversion and optoelectronic materials, TIPC, CAS.
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