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Properties of anti-washout-type calcium silicate bone cements containing gelatin

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Abstract

Novel washout-resistant bone substitute materials consisting of gelatin-containing calcium silicate cements (CSCs) were developed. The washout resistance, setting time, diametral tensile strength (DTS), morphology, and phase composition of the hybrid cements were evaluated. The results indicated that the dominant phase of β-Ca2SiO4 for the SiO2–CaO powders increased with an increase in the CaO content of the sols. After mixing with water, the setting times of the CSCs ranged from 10 to 29 min, increasing with a decrease in the amount of CaO in the sols. Addition of gelatin into the CSC significantly prolonged (P < 0.05) the setting time by about 2 and 8 times, respectively, for 5% and 10% gelatin. However, the presence of gelatin appreciably improved the anti-washout and brittle properties of the cements without adversely affecting mechanical strength. It was concluded that 5% gelatin-containing CSC may be useful as bioactive bone repair materials.

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Acknowledgements

The authors acknowledge with appreciation the support of this research by the National Science Council of the Republic of China under the grant No. NSC 97-2320-B-040-001-MY2.

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Authors and Affiliations

  1. Department of Dentistry, Chung-Shan Medical University Hospital, Taichung, 402, Taiwan, Republic of China

    Chun-Cheng Chen & Shinn-Jyh Ding

  2. Institute of Oral Biology and Biomaterials Science, Chung-Shan Medical University, No. 110, Sec. 1, Jinguo North Road, Taichung, 402, Taiwan, Republic of China

    Meng-Heng Lai, Wei-Chung Wang & Shinn-Jyh Ding

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  1. Chun-Cheng Chen
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Correspondence to Shinn-Jyh Ding.

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Chen, CC., Lai, MH., Wang, WC. et al. Properties of anti-washout-type calcium silicate bone cements containing gelatin. J Mater Sci: Mater Med 21, 1057–1068 (2010). https://doi.org/10.1007/s10856-009-3948-1

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  • DOI: https://doi.org/10.1007/s10856-009-3948-1

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