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Injectable biomaterials for minimally invasive orthopedic treatments

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Abstract

Biodegradable and injectable hydroxy terminated-poly propylene fumarate (HT-PPF) bone cement was developed. The injectable formulation consisting HT-PPF and comonomer, n-vinyl pyrrolidone, calcium phosphate filler, free radical catalyst, accelerator and radiopaque agent sets rapidly to hard mass with low exothermic temperature. The candidate bone cement attains mechanical strength more than the required compressive strength of 5 MPa and compressive modulus 50 MPa. The candidate bone cement resin elicits cell adhesion and cytoplasmic spreading of osteoblast cells. The cured bone cement does not induce intracutaneous irritation and skin sensitization. The candidate bone cement is tissue compatible without eliciting any adverse tissue reactions. The candidate bone cement is osteoconductive and inductive and allow osteointegration and bone remodeling. HT-PPF bone cement is candidate bone cement for minimally invasive radiological procedures for the treatment of bone diseases and spinal compression fractures.

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Acknowledgements

The authors are grateful to the Director, Sree Chitra Tirunal Institute for Medical sciences and Technology and Head, Biomedical Technology Wing, SCTIMST, Trivandrum, for providing the support and facilities. Technical assistance by Dr. V. S. Hari Krishnan, Dr. Mira Mohanty and Dr. P. V. Mohanan for the biological evaluation is gratefully acknowledged. The author (M.J.) acknowledge the financial support of Department of Science and Technology, New Delhi, Government of India (DST No. SR/SO/HS-50/2003).

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Authors and Affiliations

  1. Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvanthapuram, 695 012, India

    M. Jayabalan, K. T. Shalumon & M. K. Mitha

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  1. M. Jayabalan
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  2. K. T. Shalumon
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  3. M. K. Mitha
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Correspondence to M. Jayabalan.

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Jayabalan, M., Shalumon, K.T. & Mitha, M.K. Injectable biomaterials for minimally invasive orthopedic treatments. J Mater Sci: Mater Med 20, 1379–1387 (2009). https://doi.org/10.1007/s10856-008-3683-z

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  • DOI: https://doi.org/10.1007/s10856-008-3683-z

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