New multifunctional textile biomaterials for the treatment of leg venous insufficiency

  • M. Nichifor
  • M. Constantin
  • G. Mocanu
  • G. Fundueanu
  • D. Branisteanu
  • M. Costuleanu
  • C. D. Radu


Acryloyl monomers have been synthesized by reaction of β-cyclodextrin and troxerutin with acryloyl chloride and grafted on a knitted material obtained from polyamide 6.6 and polyurethane fibers. Polyamide grafted with β-cyclodextrin derivative binds troxerutin as a physical complex. The obtained biomaterials have been tested in vivo on rats for their ability to deliver troxerutin (a flebotonic drug) to different skin areas (epidermis, dermis and vascular wall). The results showed that the new synthesized materials can act as multifunctional bioactive textiles that can display both compression (given by the textile material) and sustained venotonic and haemostatic properties (given by the troxerutin delivered from biomaterial to the skin).


Benzoic Acid Venous Insufficiency Acryloyl Elastic Compression Chronic Venous Insufficiency 
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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • M. Nichifor
    • 1
  • M. Constantin
    • 1
  • G. Mocanu
    • 1
  • G. Fundueanu
    • 1
  • D. Branisteanu
    • 2
  • M. Costuleanu
    • 2
  • C. D. Radu
    • 3
  1. 1.Department of Bioactive and Biocompatible Polymers“P. Poni” Institute of Macromolecular ChemistryIasiRomania
  2. 2.“Gr. T. Popa” University of Medicine and PharmacyIasiRomania
  3. 3.Faculty of Textile and Leather Engineering“Gh. Asachi” Technical UniversityIasiRomania

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