Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration
We evaluated peripheral nerve regeneration using a biodegradable multi-layer microbraided polylactic acid (PLA) fiber-reinforced conduit. Biodegradability of the PLA conduit and its effectiveness as a guidance channel were examined as it was used to repair a 10 mm gap in the rat sciatic nerve. As a result, tube fragmentation was not obvious and successful regeneration through the gap occurred in all the conduits at 8 weeks after operation. These results indicate the superiority of the PLA materials and suggest that the multi-layer microbraided PLA fiber-reinforced conduits provide a promising tool for neuro-regeneration.
KeywordsSciatic Nerve Polylactic Acid Nerve Conductive Velocity Peripheral Nerve Regeneration Nerve Stump
The authors would like to thank National Science Council of the Republic of China (Contract No. 96-2628-E-039-011-MY3, 96-2622-E-039-001-CC3) for financially supporting this research. Dr. Tsai-Chung Lee is appreciated for her assistance in analyzing the data.