Glass–ceramic scaffolds containing silica mesophases for bone grafting and drug delivery
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Glass–ceramic macroporous scaffolds were prepared using glass powders and polyethylene (PE) particles of two different sizes. The starting glass, named as Fa-GC, belongs to the system SiO2–P2O5–CaO–MgO–Na2O–K2O–CaF2 and was synthesized by a traditional melting-quenching route. The glass was ground and sieved to obtain powders of specific size which were mixed with PE particles and then uniaxially pressed in order to obtain crack-free green samples. The compact of powders underwent a thermal treatment to remove the organic phase and to sinter the Fa-GC powders. Fa-GC scaffolds were characterized by means of X-Ray Diffraction, morphological observations, density measurements, image analysis, mechanical tests and in vitro tests. Composite systems were then prepared combining the drug uptake-delivery properties of MCM-41 silica micro/nanospheres with the Fa-GC scaffold. The system was prepared by soaking the scaffold into the MCM-41 synthesis batch. The composite scaffolds were characterized by means of X-Ray Diffraction, morphological observations, mechanical tests and in vitro tests. Ibuprofen was used as model drug for the uptake and delivery analysis of the composite system. In comparison with the MCM-41-free scaffold, both the adsorption capacity and the drug delivery behaviour were deeply affected by the presence of MCM-41 spheres inside the scaffold.
KeywordsIbuprofen Simulated Body Fluid Bioactive Glass Composite Scaffold Scaffold Surface
Ministero Italiano dell’Università e della Ricerca (MIUR) (PRIN 2006) and Regione Piemonte (Ricerca Sanitaria Finalizzata) are kindly acknowledged for financial support of this research.
- 2.W.W. Lu, F. Zhao, K.D.K. Luk, Y.J. Yin, K.M.V. Cheung, G.X. Cheng, K.D. Yao, J.C.Y. Leong, Controllable porosity hydroxyapatite ceramics as spine cage: fabrication and properties evaluation. J. Mater. Sci.: Mater. Med. 14, 1039–1046 (2003). doi: 10.1023/B:JMSM.0000004000.56814.9e CrossRefGoogle Scholar
- 6.M.W. Wolf, S.D. Cook, Use of ostoinductive implants in the treatment of bone defects. Med. Prog. Technol. 20, 155–168 (1994)Google Scholar
- 11.D. Rokusek, C. Davitt, A. Bandyopadhyay, S. Bose, H.L. Hosick, Interaction of human osteoblasts with bioinert and bioactive ceramic substrates. J. Biomed. Res. 75, 588–594 (2005)Google Scholar
- 16.N.L. Porter, R.M. Pilliar, M.D. Grynpas, Fabrication of porous calcium polyphosphate implants by solid freeform fabrication: a study of processing parameters and in vitro degradation characteristics. J. Biomed. Mater. Res. 56, 504–515 (2001). doi :10.1002/1097-4636(20010915)56:4<504::AID-JBM1122>3.0.CO;2-JPubMedCrossRefGoogle Scholar
- 20.C. Vitale-Brovarone, E. Verné, L. Robiglio, P. Appendino, F. Bassi, G. Martinasso, G. Muzio, R. Canuto, Development of glass-ceramic scaffolds for bone tissue engineering: characterisation, proliferation of human osteoblasts and nodule formation. Acta Biomater. 3, 199–208 (2007). doi: 10.1016/j.actbio.2006.07.012 PubMedCrossRefGoogle Scholar
- 34.F. Di Renzo, A. Galarneau, P. Trens, F. Fajula. in Handbook of Porous Materials, ed. by F. Schuth, K. Sing, J. Weitkamp (Wiley-VCH, 2002), p. 1311Google Scholar