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Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells

  • Deendayal Mandal
  • Avudaippan Maran
  • Michael J. Yaszemski
  • Mark E. Bolander
  • Gobinda Sarkar
Article

Abstract

Nanoparticles have been extensively used for a variety of biomedical applications and there is a growing need for highly specific and efficient delivery of the nanoparticles into target cells and subcellular location. We attempted to accomplish this goal by modifying gold particles with peptide motif’s that are known to deliver a ‘cargo’ into chosen cellular location specifically, we intended to deliver nanogold particles into cells through chemical cross-linking with different peptides known to carry protein into cells. Our results suggest that specific sequence of such ‘carrier peptides’ can efficiently deliver gold nanoparticles into cells when chemically cross-linked with the metal particles.

Keywords

Gold Nanoparticles Nuclear Localization Signal Sodium Borohydride Osteosarcoma Cell Line Organosulfur Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work has been supported by NIH Grant #AR47974.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Deendayal Mandal
    • 1
    • 2
  • Avudaippan Maran
    • 1
  • Michael J. Yaszemski
    • 1
  • Mark E. Bolander
    • 1
  • Gobinda Sarkar
    • 1
  1. 1.Department of OrthopedicsMayo Clinic and FoundationRochesterUSA
  2. 2.Department of Biomedical SciencesUniversity of Rhode IslandKingstonUSA

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