Advertisement

Synthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material

  • Lekshmi Krishna
  • Muthu Jayabalan
Article

Abstract

Biodegradable poly (caprolactone diol-co-propylene fumarate-co-ethylene glycol) amphiphilic polymer with poly (ethylene glycol) and poly (caprolactone diol) chain ends (PCL–PPF–PEG) was prepared. PCL–PPF–PEG undergoes fast setting with acrylamide (aqueous solution) by free radical polymerization and produces a crosslinked hydrogel. The cross linked and freeze-dried amphiphilic material has porous and interconnected network. It undergoes higher degree of swelling and water absorption to form hydrogel with hydrophilic and hydrophobic domains at the surface and appreciable tensile strength. The present hydrogel is compatible with L929 fibroblast cells. PCL–PPF–PEG/acrylamide hydrogel is a candidate scaffold material for tissue engineering applications.

Keywords

Poly Lactic Acid Crosslink Density Poly Ethylene Glycol Tissue Engineering Application Caprolactone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors thank Prof. K. Mohandas, Director, Sree Chitra Tirunal Institute for Medical sciences and Technology and Dr. G.S. Bhuvaneshwar, Head, Biomedical Technology Wing, SCTIMST, Trivandrum for providing the support and facilities. The authors also thank Dr. Renuka Nair for her guidance and help in tissue culture. The authors acknowledge the financial support of Department of Biotechnology, New Delhi (No. BT/PR6524/Med/14/831/2005).

References

  1. 1.
    J. Leor, S. Cohen, Ann. N. Y. Acad. Sci. 1015, 312 (2004)CrossRefPubMedADSGoogle Scholar
  2. 2.
    B.S. Kim, D.J. Mooney, Trends. Biotechnol. 16, 224 (1998)CrossRefPubMedGoogle Scholar
  3. 3.
    P.B. Van Wadrem, A.H. Hogt, J. Bengeling, J. Feijen, A. Bantis, J.P. Detmers, W.G. Van Akan, Biomaterials 8, 323 (1987)CrossRefGoogle Scholar
  4. 4.
    K.Y. Lee, D.J. Mooney, Chem. Rev. 101, 1869 (2001)CrossRefPubMedGoogle Scholar
  5. 5.
    C.R. Nuttleman, D.J. Mortisen, S.M. Henry, K.S. Anseth, J. Biomed. Mater. Res. 57, 217 (2001)CrossRefGoogle Scholar
  6. 6.
    P.A. Gunatillake, R. Adhikari, Science 295, 1009 (2003)Google Scholar
  7. 7.
    M. Jayabalan, V. Thomas, P.K. Sreelatha, Bio-Med. Mater. Eng. 10, 57 (2000)Google Scholar
  8. 8.
    W.R. Gombotz, W. Guanghui, T.A. Horbett, A.S. Hoffman, J. Biomed. Mater. Res. 25, 1547 (1991)CrossRefPubMedGoogle Scholar
  9. 9.
    E.A. Merril, E.W. Salzman, ASAIO J. 6, 60 (1983)Google Scholar
  10. 10.
    S.C. Woodward, P.S. Brewer, F. Moatamed, A. Schindler, C.G. Pitt, J. Biomed. Mater. Res. 19, 437 (1985)CrossRefPubMedGoogle Scholar
  11. 11.
    M. Jayabalan, P.P. Lixymol, V. Thomas, Poly. Int. 49, 88 (2000)CrossRefGoogle Scholar
  12. 12.
    V. Thomas, M. Jayabalan, J. Biomed. Mat. Res.-Part A, Online 22, Apr, 2008Google Scholar
  13. 13.
    P.R. Muray, Manual of clinical Microbiology, 7th edn. (American Society of Microbiology, 1999), p. 1527Google Scholar
  14. 14.
    P.M. Edwards, Biochem. Pharmacol. 24, 1277 (1975)CrossRefPubMedGoogle Scholar
  15. 15.
    M.J. Miller, D.E. Carter, I.G. Sipes, Toxicol. Appl. Pharmacol. 63, 36 (1982)CrossRefPubMedGoogle Scholar
  16. 16.
    M.I. Kaplan, S.D. Murphy, F.H. Gilles, Toxicol. Appl. Pharmacol. 24, 564 (1973)CrossRefPubMedGoogle Scholar
  17. 17.
    L.H. Christensen, V.B. Breiting, A. Aasted, A. Jorgensen, I. Kebuladge, Plastic Reconst. Surg. 111(6), 1883 (2003)CrossRefGoogle Scholar
  18. 18.
    L.T. Allen, M. Tosetto, I.S. Miller, D.P. O’connor, S.C. Penney, I. Lynch, A.K. Keenan, S.R. Pennington, K.A. Dawson, W.M. Gallagher, Biomaterials 27, 3096 (2006)CrossRefPubMedGoogle Scholar
  19. 19.
    E.A. Merrill, E.W. Salzman, ASAIO J. 6, 60 (1983)Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Polymer Division, Biomedical Technology WingSree Chitra Tirunal Institute for Medical Sciences and TechnologyThiruvananthapuramIndia

Personalised recommendations