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A comparison of different nanostructured biomaterials in subcutaneous tissue

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Abstract

The nanostructured surface of a material can improve its interaction with cells and its acceptance as an implant. We compared two novel biomaterials with different nanostructures: Bioverit® II with a coating of nanoporous silica and chitosan-hydroxyapatite composite materials. Pure Bioverit® II served as a control. Platelets of these materials were implanted for 28, 85 and 300 days in the subcutaneous tissue in the neck of 38 rabbits. After excising the specimens they were fixed, embedded in epoxy resin and analyzed histologically. All coated Bioverit® II implants showed a thin capsule of connective tissue. After 300 days, these capsules tended to be thicker than in pure Bioverit® II. No signs of inflammation were observed and the materials appeared unaltered by visual inspection. In case of chitosan-hydroxyapatite composites, massive capsules consisting of dense connective tissue were found, and the material showed signs of biodegradation in form of fissures and cavities. In conclusion, the nanoporous coating showed no obvious positive effect with regard to capsule formation; the chitosan-hydroxyapatite implants provoked a stronger interaction between cells and material. However, most Bioverit® II implants showed no alterations optically, whereas chitosan-hydroxyapatite was partly degraded in all cases.

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Acknowledgements

This work was supported by the German Research Foundation (DFG-SFB Collaborative Research Centre 599). The authors would like to thank Peter Erfurt from Department of Otolaryngology, Medical School Hannover, Hannover for technical support.

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Authors and Affiliations

  1. Department of Otolaryngology, Medical School Hannover, 30623, Hannover, Germany

    Julia C. Vogt, Thomas Lenarz & Martin Stieve

  2. Small Animal Clinic, University of Veterinary Medicine Hannover, 30173, Hannover, Germany

    Julia C. Vogt & Ingo Nolte

  3. Department of Cell Biology, Center for Anatomy, Medical School Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Gudrun Brandes

  4. Institute of Inorganic Chemistry, Leibniz University Hannover, 30060, Hannover, Germany

    Ilka Krüger & Peter Behrens

Authors
  1. Julia C. Vogt
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  2. Gudrun Brandes
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  3. Ilka Krüger
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  4. Peter Behrens
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  5. Ingo Nolte
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  6. Thomas Lenarz
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  7. Martin Stieve
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Correspondence to Gudrun Brandes.

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Vogt, J.C., Brandes, G., Krüger, I. et al. A comparison of different nanostructured biomaterials in subcutaneous tissue. J Mater Sci: Mater Med 19, 2629–2636 (2008). https://doi.org/10.1007/s10856-007-3353-6

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  • DOI: https://doi.org/10.1007/s10856-007-3353-6

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