Hydrogel–elastomer composite biomaterials: 4. Experimental optimization of hydrogel–elastomer composite fibers for use as a wound dressing



We report a novel 3-D cavity wound dressing based on a hydrogel–elastomer Interpenetrating Polymer Network (IPN) fabricated into an open-mesh architecture. IPN fibers used to form the dressing were produced by a wet spinning method and optimized in two steps. A factorial experiment was first conducted to identify key parameters that controlled fiber properties. We observed that gelatin wt% played a major role in determining fiber yield, swelling, strength and stability. Other contributing factors included coagulation solution composition, gelatin type, and pre- and post-UV irradiation time. The key factors were then further evaluated individually to achieve a condition that provided a combination of good swelling, mechanical properties and stability. The concentration of the gelatin/HydroThaneTM extrusion solution significantly affected fiber formation and properties, presumably due to the changes in solution viscosity. The effects of pre-UV irradiation were also ascribed to its impact on the solution viscosity and became negligible at higher concentrations when viscosity is mainly controlled by concentration. The composition of the coagulation bath influenced the fiber swelling and wet stress. These results, taken together with our previous studies, suggest that our biomaterial would provide a combination of mechanical and swelling properties suitable for wound dressing applications.


Gelatin Solution Viscosity Attenuate Total Reflectance Interpenetrate Polymer Network Fiber Property 



The authors are indebted to Ms. Michelle Mok and Mr. Doug Saunders for their expert technical assistance.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Defence Research and Development Canada – TorontoTorontoCanada
  2. 2.Defence Research and Development Canada – ValcartierQuebecCanada

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