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The one-pot synthesis of dextran-based nanoparticles and their application in in-situ fabrication of dextran-magnetite nanocomposites

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Abstract

The dextran-based nanoparticles containing carboxyl groups were synthesized by a one-pot approach, without using any organic solvents and surfactants. The resultant dextran-based nanoparticles was used as a host for the growing and organization of Fe3O4 nanoparticles. The approach consists of the mixture of ferrous/ferric ions aqueous solution and host nanoparticles and subsequent coprecipitation of ferrous/ferric ions in basic medium. The magnetic nanocomposite material obtained was characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), X-ray diffraction techniques (XRD) and vibrating sample magnetometry (VSM). The data demonstrate that the carboxyls which can capture cationic ferrous/ferric by electronic interaction in the dextran-based hosts plays a crucial role in fabricating nanocomposites with a homogeneous spatial distribution of magnetite nanoparticles. The magnetic nanocomposites exhibit comparable saturation magnetizations to that of reported Fe3O4 nanoparticles, and therefore display great potential in a large scope of biomedical fields.

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Acknowledgements

This work was financially supported by Science and Technology Committee of Shanghai (Project No. 05ZR14084). We thank Instrumental Analysis Center of SJTU for the assistance on measurements.

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Authors and Affiliations

  1. State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China

    Hongjing Dou, Bin Xu, Ke Tao, Minhua Tang & Kang Sun

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  1. Hongjing Dou
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  2. Bin Xu
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  3. Ke Tao
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  4. Minhua Tang
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  5. Kang Sun
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Correspondence to Kang Sun.

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Dou, H., Xu, B., Tao, K. et al. The one-pot synthesis of dextran-based nanoparticles and their application in in-situ fabrication of dextran-magnetite nanocomposites. J Mater Sci: Mater Med 19, 2575–2580 (2008). https://doi.org/10.1007/s10856-007-3202-7

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