In vivo degradation of poly(DTE carbonate) membranes. Analysis of the tissue reactions and mechanical properties

  • Antti J. Asikainen
  • Mika Pelto
  • Jukka Noponen
  • Minna Kellomäki
  • Harri Pihlajamäki
  • Christian Lindqvist
  • Riitta Suuronen


Different bioabsorbable polymers and their co-polymers have been used to construct an optimal material for guided bone regeneration applications. Our aim was to evaluate a novel bioabsorbable material in a soft tissue environment. In this study, a poly(DTE carbonate) membrane (0.2–0.3 mm) was implanted into 20 NZW rabbits’ subcutaneous pouches for 6, 12, 24 and 52 weeks. The material was evaluated by means of histological reactions to the material and mechanical properties of the membrane. Based on this study, it can be concluded that poly(DTE carbonate) elicited a very modest foreign body reaction in the soft tissues. This reaction was uniform throughout the study. Varying amounts of calcification was seen in the fibrous capsule surrounding the implant. The number of calcified bodies did not correlate to healing time.


Poly Lactic Acid Fibrous Capsule Guide Bone Regeneration Calcify Body Connective Tissue Capsule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This study was supported by the State Subsidiary Grant (TYH1331 and TYH4307), Finnish Dental Society Apollonia and National Technology Agency of Finland. Authors wish to thank Histola Ltd, Tampere, Finland for preparing the samples. Finally, we would like to thank Antti Kourula, MD, for English proof reading of this article.


  1. 1.
    R. K. KULKARNI, K. C. PANI, C. NEUMAN, et al., Arch. Surg. 5 (1966) 839Google Scholar
  2. 2.
    E. J. FRAZZA and E. E. SCHMITT, J. Biomed. Mater. Res. 2 (1971) 43CrossRefGoogle Scholar
  3. 3.
    H. DARDIK, I. DARDIK and H. LAUFMAN, Am. J. Surg. 6 (1971) 656CrossRefGoogle Scholar
  4. 4.
    D. E. CUTRIGHT, E. E. HUNSUCK and J. D. BEASLEY, J. Oral Surg. 6 (1971) 393Google Scholar
  5. 5.
    D. E. CUTRIGHT and E. E. HUNSUCK, Oral Surg. Oral Med. Oral Pathol. 1 (1972) 28CrossRefGoogle Scholar
  6. 6.
    A. DIETZ, C. M. ZIEGLER, A. DACHO, et al., J. Craniomaxillofac. Surg. 2 (2001) 82Google Scholar
  7. 7.
    V. K. PRUTHI, S. C. GELSKEY and S. M. MIRBOD, J. Can. Dent. Assoc. 10 (2002) 610Google Scholar
  8. 8.
    W. THARANON, D. P. SINN, P. C. HOBAR, et al., J. Craniofac. Surg. 5 (1998) 441CrossRefGoogle Scholar
  9. 9.
    M. EKHOLM, J. HIETANEN, C. LINDQVIST, et al., J. Mater. Sci. Mater. Med. 2 (1999) 69CrossRefGoogle Scholar
  10. 10.
    N. ASHAMMAKHI, E. A. MÄKELA, K. VIHTONEN, et al., Ann. Chir. Gynaecol. 3 (1995) 309Google Scholar
  11. 11.
    R. KONTIO, R. SUURONEN, O. SALONEN, et al., Int. J. Oral. Maxillofac. Surg. 4 (2001) 278CrossRefGoogle Scholar
  12. 12.
    R. KONTIO, R. SUURONEN, Y. T. KONTTINEN, et al., Int. J. Oral. Maxillofac. Surg. 4 (2004) 361CrossRefGoogle Scholar
  13. 13.
    T. A. ST JOHN, A. R. VACCARO, A. P. SAH, et al., Am. J. Orthop. 1 (2003) 18Google Scholar
  14. 14.
    J. KOHN and R. LANGER, J. Am. Chem. Soc. 3 (1987) 817CrossRefGoogle Scholar
  15. 15.
    S. I. ERTEL and J. KOHN, J. Biomed. Mater. Res. 8 (1994) 919CrossRefGoogle Scholar
  16. 16.
    K. JAMES, H. LEVENE, J. R. PARSONS, et al., Biomaterials 23–24 (1999) 2203CrossRefGoogle Scholar
  17. 17.
    S. L. BOURKE, J. KOHN and M. G. DUNN, Tissue Eng. 1–2 (2004) 43CrossRefGoogle Scholar
  18. 18.
    T. PYHÄLTÖ, M. LAPINSUO, H. PATIALA, et al., Biomaterials 6 (2005) 645CrossRefGoogle Scholar
  19. 19.
    V. TANGPASUTHADOL, S. M. PENDHARKAR and J. KOHN, Biomaterials 23 (2000) 2371CrossRefGoogle Scholar
  20. 20.
    K. A. HOOPER, N. D. MACON and J. KOHN, J. Biomed. Mater. Res. 3 (1998) 443CrossRefGoogle Scholar
  21. 21.
    V. TANGPASUTHADOL, S. M. PENDHARKAR, R. C. PETERSON, et al., Biomaterials 23 (2000) 2379CrossRefGoogle Scholar
  22. 22.
    J. FIORDELISO, S. BRON and J. KOHN, J. Biomater. Sci. Polym. Ed. 6 (1994) 497Google Scholar
  23. 23.
    J. KOHN, Trends Polym. Sci. 1 (1993) 206Google Scholar
  24. 24.
    A. J. ASIKAINEN, J. NOPONEN, K. MESIMÄKI, et al., J. Mater. Sci.: Mater. Med. 16 (2005) 753CrossRefGoogle Scholar
  25. 25.
    T. PYHÄLTÖ, M. LAPINSUO, H. PATIALA, et al., J. Orthop. Sci. 5 (2002) 549Google Scholar
  26. 26.
    J. CHOUEKA, J. L. CHARVET, K. J. KOVAL, et al., J. Biomed. Mater. Res. 1 (1996) 35CrossRefGoogle Scholar
  27. 27.
    H. A. DECLERCQ, R. M. H. VERBEECK, L. I. F. J. M. DE RIDDER, et al., Biomaterials 24 (2005) 4964CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Antti J. Asikainen
    • 1
    • 4
  • Mika Pelto
    • 3
  • Jukka Noponen
    • 1
  • Minna Kellomäki
    • 3
  • Harri Pihlajamäki
    • 4
  • Christian Lindqvist
    • 1
    • 2
  • Riitta Suuronen
    • 5
  1. 1.Department of Oral and Maxillofacial SurgeryUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of Oral and Maxillofacial SurgeryHelsinki University Central HospitalHelsinkiFinland
  3. 3.Institute of BiomaterialsTampere University of TechnologyTampereFinland
  4. 4.Research Institute of Military MedicineCentral Military HospitalHelsinkiFinland
  5. 5.Institute for Regenerative MedicineTampere University and University HospitalTampereFinland

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