In vivo degradation of poly(DTE carbonate) membranes. Analysis of the tissue reactions and mechanical properties
- 202 Downloads
Different bioabsorbable polymers and their co-polymers have been used to construct an optimal material for guided bone regeneration applications. Our aim was to evaluate a novel bioabsorbable material in a soft tissue environment. In this study, a poly(DTE carbonate) membrane (0.2–0.3 mm) was implanted into 20 NZW rabbits’ subcutaneous pouches for 6, 12, 24 and 52 weeks. The material was evaluated by means of histological reactions to the material and mechanical properties of the membrane. Based on this study, it can be concluded that poly(DTE carbonate) elicited a very modest foreign body reaction in the soft tissues. This reaction was uniform throughout the study. Varying amounts of calcification was seen in the fibrous capsule surrounding the implant. The number of calcified bodies did not correlate to healing time.
KeywordsPoly Lactic Acid Fibrous Capsule Guide Bone Regeneration Calcify Body Connective Tissue Capsule
This study was supported by the State Subsidiary Grant (TYH1331 and TYH4307), Finnish Dental Society Apollonia and National Technology Agency of Finland. Authors wish to thank Histola Ltd, Tampere, Finland for preparing the samples. Finally, we would like to thank Antti Kourula, MD, for English proof reading of this article.
- 1.R. K. KULKARNI, K. C. PANI, C. NEUMAN, et al., Arch. Surg. 5 (1966) 839Google Scholar
- 4.D. E. CUTRIGHT, E. E. HUNSUCK and J. D. BEASLEY, J. Oral Surg. 6 (1971) 393Google Scholar
- 6.A. DIETZ, C. M. ZIEGLER, A. DACHO, et al., J. Craniomaxillofac. Surg. 2 (2001) 82Google Scholar
- 7.V. K. PRUTHI, S. C. GELSKEY and S. M. MIRBOD, J. Can. Dent. Assoc. 10 (2002) 610Google Scholar
- 10.N. ASHAMMAKHI, E. A. MÄKELA, K. VIHTONEN, et al., Ann. Chir. Gynaecol. 3 (1995) 309Google Scholar
- 13.T. A. ST JOHN, A. R. VACCARO, A. P. SAH, et al., Am. J. Orthop. 1 (2003) 18Google Scholar
- 22.J. FIORDELISO, S. BRON and J. KOHN, J. Biomater. Sci. Polym. Ed. 6 (1994) 497Google Scholar
- 23.J. KOHN, Trends Polym. Sci. 1 (1993) 206Google Scholar
- 25.T. PYHÄLTÖ, M. LAPINSUO, H. PATIALA, et al., J. Orthop. Sci. 5 (2002) 549Google Scholar