Vaterite deposition on biodegradable polymer foam scaffolds for inducing bone-like hydroxycarbonate apatite coatings
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Hydroxycarbonate apatite (HCA) coatings on the surface of bioresorbable materials for bone tissue engineering scaffolds were produced using macroporous poly(DL-lactide) (PDLLA) foams impregnated by calcium carbonate in vaterite crystalline form. Stable and homogeneous vaterite deposition on PDLLA foams was achieved using a slurry dipping technique. In vitro studies in simulated body fluid (SBF) were performed to induce formation of (HCA) on the surface of vaterite/PDLLA composite foams. HCA was detected after immersion of foams in SBF for 7 days. Hence, depositing vaterite on materials followed by immersion in SBF is confirmed to induce HCA coatings on the surface of the material. The HCA coated, bioactive and resorbable PDLLA foams are intended for use as bone tissue engineering scaffolds.
KeywordsFoam Simulated Body Fluid Bone Tissue Engineering Vaterite Simulated Body Fluid Solution
The authors are indebted to Dr. Yoshio Ota of Yabashi Industries, Co., Ltd. for helpful discussions. The present work was supported in part by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science and by a grant from the NITECH 21st Century COE Program “World Ceramics Center for Environmental Harmony”.
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