Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes

  • Manuela C. C. M. Sobral
  • Abilio J. F. N. Sobral
  • J. T. Guthrie
  • M. H. Gil


Ketotifen was immobilised in cellulose acetate propionate (CAP) membranes and in cellulose acetate butyrate (CAB) membranes. The characteristics of each system were evaluated under a range of experimental conditions. The topography and uniformity of the membranes was assessed using scanning electron microscopy. The release characteristics associated with Ketotifen were monitored spectrophotometrically. The swelling capacity of the membranes was evaluated and attributed to the combined effects of diffusion and of complex dissociation, during swelling. The materials produced were able to provide controlled release of Ketotifen due to their controlled swelling behaviour and adequate release properties. The results showed that the release of Ketotifen from the CAB membranes is higher but the release from the CAP membranes is more uniform.


Drug Release Atopic Dermatitis Cellulose Acetate Water Sorption Ketotifen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



A. Sobral thanks Fundação para a Ciência e Tecnologia (POCI/AMB/55281/2004) for financial support.


  1. 1.
    R. L. N. A. PEPPAS, AIChE J. 49 (2003) 2992Google Scholar
  2. 2.
    G. V. PATIL, Drug Develop. Res. 58 (2003) 219CrossRefGoogle Scholar
  3. 3.
    C. THOMASIN, H. NAM-TRAON, H. P. MERKLE and B. GANDER, J. Pharma. Sci. 87 (1998) 259CrossRefGoogle Scholar
  4. 4.
    F. HUDECZ, J. REMENYI, R. SZABO, G. KOCZAN, G. MEZO, P. KOVACS and D. GAAL, Mol. Recognit. 16 (2003) 288CrossRefGoogle Scholar
  5. 5.
    D. M. ARM and A. F. TENCER, J. Biomed. Mater. Res. 35 (1997) 433–441CrossRefGoogle Scholar
  6. 6.
    A. J. SHUKLA, Pharmaceut. Res. 8 (1991) 1396CrossRefGoogle Scholar
  7. 7.
    R. E. O’CONNOR, Pharmaceut. Res. 10 (1993) 356CrossRefGoogle Scholar
  8. 8.
    R. SINGHAL, J. Thermal Anal. Calorimetry, 58 (1999) 29CrossRefGoogle Scholar
  9. 9.
    S. Y. LIN, Pharmaceut. Res. 4 (1987) 70CrossRefGoogle Scholar
  10. 10.
    C. M. SINKO, Pharmaceut. Res. 8 (1991) 698CrossRefGoogle Scholar
  11. 11.
    A. T. PHAM, Pharmaceut. Res. 11 (1994) 1379CrossRefGoogle Scholar
  12. 12.
    S. S. AL-NIMRY, S. M. ASSAF, I. M. JALAL and N. M. NAJIB, Inter. J. Pharmaceut. 149 (1997) 115CrossRefGoogle Scholar
  13. 13.
    X. CHEN, D. ZHONG, D. LIU, Y. WANG, Y. HAN and J. GU, Rapid Commun. Mass Spectrom. 17 (2003) 2459CrossRefGoogle Scholar
  14. 14.
    S. TZVETANOV, M. VATSOVA, A. DRENSKA, J. GORANTCHEVA and N. TYUTYULKOVA, J. Chromatograp. B. 732 (1999) 251CrossRefGoogle Scholar
  15. 15.
    F. Q. ALALI, B. M. TASHTOUSH and N. M. NAJIB, J. Pharmaceut. Biomed. Analy. 34 (2004) 87CrossRefGoogle Scholar
  16. 16.
    M. JOSHI and A. MISRA, Inter. J. Pharmaceut. 223 (2001) 15CrossRefGoogle Scholar
  17. 17.
    U. BREYER-PFAFF and K. NILL, Biochem Pharmacol. 59 (2000) 249CrossRefGoogle Scholar
  18. 18.
    S. M. GRANT, K. L. GOA, A. FITTON and E. M. SORKIN, Drugs. 40 (1990) 412CrossRefGoogle Scholar
  19. 19.
    I. LE BLAYE, B. DONATINI, M. HALL and P. KRUPP, Drug Saf. 7 (1992) 387CrossRefGoogle Scholar
  20. 20.
    S. T. WEISS, A. A. LITONJUA, C. LANGE, R. LAZARUS, S. B. LIGGETT, E. R. BLEECKER and K. G. TANTISIRA, Pharmacogenom. J. 6 (2006) 311Google Scholar
  21. 21.
    M. C. C. M. SOBRAL, 1994, Drug controlled release from cellulose based systems, MSc Thesis, (FCTUC, Ed. University of Coimbra)Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Manuela C. C. M. Sobral
    • 1
  • Abilio J. F. N. Sobral
    • 2
  • J. T. Guthrie
    • 3
  • M. H. Gil
    • 4
  1. 1.Escola Infante D. PedroPenelaPortugal
  2. 2.The Department of ChemistryUniversity of Coimbra, FCTUCCoimbraPortugal
  3. 3.The Polymer Group, The Department of Colour ChemistryThe University of LeedsLeedsUK
  4. 4.The Department of Chemical EngineeringUniversity of Coimbra, FCTUCCoimbraPortugal

Personalised recommendations