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Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes

  • Manuela C. C. M. Sobral
  • Abilio J. F. N. Sobral
  • J. T. Guthrie
  • M. H. Gil
Article

Abstract

Ketotifen was immobilised in cellulose acetate propionate (CAP) membranes and in cellulose acetate butyrate (CAB) membranes. The characteristics of each system were evaluated under a range of experimental conditions. The topography and uniformity of the membranes was assessed using scanning electron microscopy. The release characteristics associated with Ketotifen were monitored spectrophotometrically. The swelling capacity of the membranes was evaluated and attributed to the combined effects of diffusion and of complex dissociation, during swelling. The materials produced were able to provide controlled release of Ketotifen due to their controlled swelling behaviour and adequate release properties. The results showed that the release of Ketotifen from the CAB membranes is higher but the release from the CAP membranes is more uniform.

Keywords

Drug Release Atopic Dermatitis Cellulose Acetate Water Sorption Ketotifen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

A. Sobral thanks Fundação para a Ciência e Tecnologia (POCI/AMB/55281/2004) for financial support.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Manuela C. C. M. Sobral
    • 1
  • Abilio J. F. N. Sobral
    • 2
  • J. T. Guthrie
    • 3
  • M. H. Gil
    • 4
  1. 1.Escola Infante D. PedroPenelaPortugal
  2. 2.The Department of ChemistryUniversity of Coimbra, FCTUCCoimbraPortugal
  3. 3.The Polymer Group, The Department of Colour ChemistryThe University of LeedsLeedsUK
  4. 4.The Department of Chemical EngineeringUniversity of Coimbra, FCTUCCoimbraPortugal

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