Ketotifen controlled release from cellulose acetate propionate and cellulose acetate butyrate membranes
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Ketotifen was immobilised in cellulose acetate propionate (CAP) membranes and in cellulose acetate butyrate (CAB) membranes. The characteristics of each system were evaluated under a range of experimental conditions. The topography and uniformity of the membranes was assessed using scanning electron microscopy. The release characteristics associated with Ketotifen were monitored spectrophotometrically. The swelling capacity of the membranes was evaluated and attributed to the combined effects of diffusion and of complex dissociation, during swelling. The materials produced were able to provide controlled release of Ketotifen due to their controlled swelling behaviour and adequate release properties. The results showed that the release of Ketotifen from the CAB membranes is higher but the release from the CAP membranes is more uniform.
KeywordsDrug Release Atopic Dermatitis Cellulose Acetate Water Sorption Ketotifen
A. Sobral thanks Fundação para a Ciência e Tecnologia (POCI/AMB/55281/2004) for financial support.
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