Increase of the final setting time of brushite cements by using chondroitin 4-sulfate and silica gel

  • F. Tamimi-Mariño
  • J. Mastio
  • C. Rueda
  • L. Blanco
  • E. López-Cabarcos
Original Paper


Chondroitin 4-sulfate (C4S) is a bioactive glycosaminoglycan with inductive properties in bone and tissue regeneration. Dicalcium phosphate dehydrate cements (known as brushite) are biocompatible and resorbable materials used in bone and dental surgery. In this study we analyzed the effect of C4S on the setting of a calcium phosphate cement and the properties of the resulting material. Brushite based cement powder was synthesised by mixing monocalcium phosphate with β-tricalcium phosphate and sodium pyrophosphate. When the concentration of C4S, in the liquid added to the cement powder, was between 1 and 8% the cement final setting time increases. Furthermore, the cement diametral tensile strength remains unaffected when solutions with concentrations of C4S below 5% were used, but decreases at higher C4S concentrations. Calorimetric analysis showed that the cements prepared with C4S alone and in combination with silica gel have a greater content of hydrated water. We concluded from our study that the addition of small amounts of C4S increases the cement setting time without affecting its diametral tensile strength and at the same time improves the cement’s hydrophilicity.


Chondroitin Sulfate Calcium Phosphate Cement DCPD Cement Sample Calcium Oxalate Monohydrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors acknowledge financial support from the Spanish Science and Technology Ministry (MAT2006–13646–C03–01) and Comunidad de Madrid (GR/MAT/0501/2004).


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • F. Tamimi-Mariño
    • 1
    • 2
  • J. Mastio
    • 1
  • C. Rueda
    • 1
  • L. Blanco
    • 2
  • E. López-Cabarcos
    • 1
  1. 1.Departamento de Física Química II, Facultad de FarmaciaUniversidad Complutense de MadridMadridSpain
  2. 2.Facultad de OdontologíaUniversidad Complutense de MadridMadridSpain

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