Advertisement

Morphometrical analysis of multinucleated giant cells in subdermal implants of poly-lactic acid in rats

  • L. C. V. Maluf-Meiken
  • D. R. M. Silva
  • E. A. R. Duek
  • M. C. Alberto-Rincon
Article

Abstract

The use of bioabsorbable polymers in (bio)medical applications has increased greatly in recent years, mainly because of their good bioreabsorption and biocompatibility. In this work, we examined the development of foreign body giant cells in intimate contact with porous membranes of poly L–lactic acid containing 7% of plasticizer triethylcitrate implanted in the backs of rats. The membranes were removed 2, 7, 14, 21, 28, 60, 90 and 180 days after implantation, along with a portion of the tissue around the implant. Histological analysis of the implant and tissue revealed the formation of a fibrous capsule from the seventh day of implantation onwards. Foreign body giant cells appeared from the seventh day and increased in number up to the twenty-eighth day and then up to the ninetieth day of implantation, remaining constant up to the end of the study onwards, and increased in number up to the ninetieth day after implantation and then remained constant. The number of nuclei in these cells increased from the seventh day of implantation up to the ninetieth day and then up to the end of the study.

Keywords

Polymer Lactic Acid Foreign Body Giant Cell Histological Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    K. A. ATHANASIOU, G. G. NIEDERAUER and C. M. AGRAWAL, Biomaterials 17 (1996) 93.CrossRefGoogle Scholar
  2. 2.
    H. PISTNER, R. GUTWALD, R. ORDUNG, J. REUTHER and J. M. ÜHLING, Biomaterials 14 (1992) 671.CrossRefGoogle Scholar
  3. 3.
    J. M. BRADY, D. E. CUTRIGHT, R. A. MILLER and G. C. BARRISTONE, J. Biomed. Mat. Res. 7 (1973) 155.CrossRefGoogle Scholar
  4. 4.
    M. VAN DER ELST, A. R. DIJKEMA, C. P. KLEIN, P. PATKA and H. J. HAARMAN, Biomaterials 16 (1995) 103.CrossRefGoogle Scholar
  5. 5.
    G. J. BEUMER, C. A. VAN BLITTERSWIJK and M. PONEC, Biomaterials 15 (1994) 551.CrossRefGoogle Scholar
  6. 6.
    R. M. LUCIANO, in “Síntese,12 Caracterizaç ao e Degradaç ao de Membranas de Poliácido lático), um polímero bioabsorvível”, Masters dissertation. UNICAMP. 1997.Google Scholar
  7. 7.
    H. A. VON RECUM, R. L. CLEEK and S. G. ESKIN, A. G. MIKOS, Biomaterials 16 (1995) 441.CrossRefGoogle Scholar
  8. 8.
    D. R. M. SILVA, S. M. N. SCAPIN, P. P. JOAZEIRO, R. M. LUCIANO, E. A. R. DUEK and M. C. ALBERTO-RINCON, J. Mat. Sci: Mat. Med. 13 (2002) 327.CrossRefGoogle Scholar
  9. 9.
    P. MAINIL-VARLET, S. GOGOLEWSKI and P. NIEUWENHUIS, J. Mat. Sci.: Mat. Med. 7 (1996) 713.CrossRefGoogle Scholar
  10. 10.
    N. AL-SAFFAR and P. A. REVELL, J. Orthop. Res. 18 (2000) 800.CrossRefGoogle Scholar
  11. 11.
    S. H. HYLON, K. JAMSHIDI and Y. IKADA, in “Polymers as Biomaterials” (Plenum Press, 1985) p. 51.Google Scholar
  12. 12.
    K. H. LAM, J. M. SCHAKENRAAD, H. ESSELBRUGGE, J. FEIJEN and P. NIEUWENHUIS, J. Biomed. Mat. Res. 27 (1993) 1569.CrossRefGoogle Scholar
  13. 13.
    J. M. SCHAKENRAAD, M. J. HARDONK, J. FEIJEN, I. MOLENAAR and P. NIEUWENHUIS, J. Biomed. Mat. Res. 24 (1990) 529.CrossRefGoogle Scholar
  14. 14.
    W. J. KAO, D. LEE, Biomaterials 22 (2001) 2901.CrossRefGoogle Scholar
  15. 15.
    A. K. McNALLY and J. M. ANDERSON, Am. J. Pathol. 160 (2002) 621.Google Scholar
  16. 16.
    A. GASSER and J. MOST, Infect. Immun. 67 (1999) 395.Google Scholar
  17. 17.
    R. M. LUCIANO, in “Proceedings of the European Medical & Biological Engineering Conference”, Vienna, November 1999, edited by P. Peregrius (Published for International Federation for Medical & Biological Engineering, 1999) p. 214.Google Scholar
  18. 18.
    M. C. C. SPECTOR and X. TONG-LI, Crit. Rev. Biocomp. 5 (1989) 269.Google Scholar
  19. 19.
    W. J. KAO, Biomaterials 20 (1999) 2213.CrossRefGoogle Scholar
  20. 20.
    G. J. BEUMER, C. A. van BLITTERSWIJK and M. PONEC, J. Biomed. Mat. Res. 28 (1994) 545.CrossRefGoogle Scholar
  21. 21.
    J. E. BERGSMA, F. R. ROZEMA, R. R. BOS, G. BOERING, W. C. de BRUIJN and A. J. PENNINGS, J. Biomed. Mat. Res. 29 (1995) 173.CrossRefGoogle Scholar
  22. 22.
    E. SOLHEIM, B. SUDMANN, G. BANG and E. SUDMANN, J. Biomed. Mat. Res. 49 (2000) 257.CrossRefGoogle Scholar
  23. 23.
    D. R. JORDAN, S. BROWNSTEIN, S. GILBERG, B. MATTHEW, L. MAWN and L. KHOURI, Ophthal. Plast. Reconstr. Surg. 18 (2002) 342.Google Scholar
  24. 24.
    T. G. van Tienen, R. G. Heijkants, P. Buma, J. H. de Groot, A. J. Pennings and R. P. Veth, Biomaterials 23 (2002) 1731.CrossRefGoogle Scholar
  25. 25.
    J. M. BRADY, D. E. CUTRIGHT, R. A. MILLER and G. C. BARRISTONE, J. Biomed. Mat. Res. 7 (1973) 155.CrossRefGoogle Scholar
  26. 26.
    S. NAKAMURA, S. NINOMIYA, Y. TAKATORI, S. MORIMOTO, I. KUSABA and T. KUROKAWA, Acta Orthop. Scand. 64 (1993) 301.CrossRefGoogle Scholar
  27. 27.
    K.M. De FIFE, C.R. JENNEY, E. COLTON and J.M. ANDERSON, FASEB J. 13 (1999) 823.Google Scholar
  28. 28.
    A.K. McNALLY and J.M. ANDERSON, Am. J. Pathol. 147 (1995) 1487.Google Scholar
  29. 29.
    K.M. De FIFE, C.R. JENNEY, A.K. McNALLY, E. COLTON and J.M. ANDERSON, J. Immunol. 158 (1997) 3385.Google Scholar
  30. 30.
    W.J. KAO, A.K. McNALLY, A. HILTNER and J.M. ANDERSON, J. Biomed. Mat. Res. 29 (1995) 1267.CrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • L. C. V. Maluf-Meiken
    • 1
  • D. R. M. Silva
    • 2
  • E. A. R. Duek
    • 1
  • M. C. Alberto-Rincon
    • 2
  1. 1.Laboratory of BiomaterialsCenter of Medical and Biological Sciences, PUC/SPSorocabaBrazil
  2. 2.Department of Histology and EmbryologyInstitute of Biology, State University of Campinas (UNICAMP)CampinasBrazil

Personalised recommendations