Abstract
A novel hydrogel based on 2-hydroxyethyl- methacrilate and SiO2 nanoparticles was prepared. The filler was added at a concentration of 30% w/w of silica nanoparticles to the mass of polymer. The composite material was characterised as far as concerns swelling behaviour in comparison to pHEMA. Swelling ratio of modified pHEMA was higher. Bioactivity of both SiO2 nanoparticles and the modified hydrogel was evaluated by soaking samples into a simulated body fluid (SBF). FT-IR spectroscopy, scanning electron microscopy (SEM) and energy dispersive system (EDS) results suggest silica nanoparticles keep bioactive in the polymer. SiO2 filler in a p(HEMA) matrix makes the composite bioactive. Therefore, these composites can be used to make bioactive scaffold for bone engineering.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Y. E. GREISH, J. D. BENDER, S. LAKSHMI, P. W. BROWN and H. R. ALLCOCK, C. T. Laurencin Biomaterials 26(1) (2004) 1.
O. PEITL, R. L. OREFICE, L. L. HENCH and A. B. BRENNAN, Materials Science & Engineering, A: Structural Materials: Properties, Microstructure and Processing A372(1–2) (2004) 245.
H. AHMAD, M. A. J. MIAH and M.M. RAHMAN, Colloid and Polymer Science 281(10) (2003) 988.
O. WICHTERLE and D. LIM, Nature (1960) 185.
Hydrogels in medicine and pharmacy, edited by N. A. Peppas, Volumes I and II (CRC Press Boca Raton, FL, 1987).
P. A. NETTI, J. C. SHELTON, P. A. REVELL, C. PIRIE, S. SMITH, L. AMBROSIO, L. NICOLAIS and W. BONFIELD, Biomaterials 14 (14) (1993) 1098.
J. P. MONTHÉARD, M. CHATZOPOULOS, D. CHAPPARD and J. MACROMOL. Sci. Macromol. Rev. C32(1) (1992) 1.
L. L. HENCH, J. Am. Ceram. Soc. 74(7) (1991) 1487.
T. KOKUBO, in Proceedings of the XVI International Congress on Glass, Madrid 1992, Volume 1, S. E. de Ceramica y Vidrio. p. 119.
F. BRANDA, A. COSTANTINI, G. LAUDISIO, A. BURI, L. AMBROSIO and J. MAT. Sci. 34 (1999) 1319.
F. BRANDA, A. COSTANTINI, G. LUCIANI, L. AMBROSIO and J. BIOMED. Mater. Res. 57 (1) (2001) 79.
V. P. PRIVALKO, V. F. SHUNSKY, E. G. PRIVALKO, V. M. KARAMAN, R. WALTER, K. FRIEDRICH, M. Q. ZHANG and M. Z. RONG, Sci. Tech. Adv. Mater 3 (2002) 111.
W. STOBER, A. FINK and E. BOHN, J. Colloid and Interface Science 26 (1968) 62.
C. OHTSUKI, T. KOKUBO and T. YAMAMURO. J. Non-Cryst. Solids 143 (1992) 84.
C. Y. KIM, A. E. CLARK and L. L. HENCH, J. Non-Cryst. Solids 113(2–3) (1989) 195.
R. A. NYQUIST and R. O. KAGEL in “Infrared Spectra of Inorganic Compounds” (Academic Press Inc., San Diego, California, 1991).
N. P. BANSAL, J. Mat. Sci. 27 (1992) 2922.
Y. HUANG, Z. JIANG and W. SCHWIEGER, Chem. Mater. 11 (1999) 1210.
P. HAJJI, L. DAVID, J. F. GERARD, J. P. PASCAULT and G. VIGIER and J. Polym. Sci. B: Polym. Phys. 37 (1999) 3172.
P. BOSCH, F. DEL MONTE, J. L. MATEO and D. J LEVY., Polym. Sci. Part A: Polym. Chem. 34 (1996) 3289.
B. M. NOVAK and M. W. ELLSWORTH, C. VERRIER, In “Hybrid organic-inorganic Composites” edited by J. E. Mark, Y-C Lee, P. A. Bianconi (ACS Symposium Series 585, Am. Chem. Soc: Washington, DC, 1995) p 86.
P. A. DAVIS, S. J. HUANG, L. NICOLAIS and L. AMBROSIO, in “High performance biomaterials”, edited by M. Szycher (Technomic Publishing Co Lancaster, P. A., 1991) p. 343.
H. RAWSON in “Properties and Applications of Glass” (Elsevier, New York, 1980).
A. PAUL in “Chemistry of Glasses 2nd Ed” (Chapman & Hall, London, 1990).
M. TANAHASHI, T. YAO, T. KOKUBO, M. MINODA, T. MIYAMOTO, T. NAKAMURA and T. YAMAMURO, J. Mat. Sci. Mater. Med. 6 (6) (1995) 319.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Costantini, A., Luciani, G., Annunziata, G. et al. Swelling properties and bioactivity of silica gel/pHEMA nanocomposites. J Mater Sci: Mater Med 17, 319–325 (2006). https://doi.org/10.1007/s10856-006-8230-1
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10856-006-8230-1