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Is surface chemical composition important for orthopaedic implant materials?

  • D. O. Meredith
  • M. O. Riehle
  • A. S. G. Curtis
  • R. G. Richards
Article

Abstract

Ti-6Al-7Nb (NS) in its ‘standard’ implant form has been previously shown to be detrimental to fibroblast growth and colonisation on its surface. Specific aspects of the NS topography have been implicated, however, the contribution of its unique surface chemistry to the cell behaviour was unknown. By evaporating either gold or titanium on the surface of standard NS, two different model surface chemistries could be studied with the same characteristic standard NS topography. Two other ‘standard’ orthopaedic topographies, that of stainless steel (SS) and of ‘commercially pure’ titanium (TS) were also treated in a similar manner. All materials elicited behaviour similar to their uncoated counterparts. For coated SS and TS, cell proliferation was observed, cells were well spread and displayed mature focal adhesion sites, and associated cytoskeletal components. For coated NS, cell proliferation was compromised, cells remained rounded, filopodia attached and seemed to probe the surface, especially the β -phase particles, and both the focal adhesion sites and the microtubule network were disrupted by the presence of these particles. These results confirmed, that in the instance of NS, the topography was the primary cause for the observed stunted cell growth. For biomaterials studies, the standardisation of surface chemistry used here is a valuable tool in allowing vastly different materials and surface finishes to be compared solely on the basis of their topography.

Keywords

Microtubule Network Uncoated Sample Focal Adhesion Site Coated Stainless Steel Atomic Number Contrast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • D. O. Meredith
    • 1
    • 2
  • M. O. Riehle
    • 2
  • A. S. G. Curtis
    • 2
  • R. G. Richards
    • 1
  1. 1.AO Research InstituteAO Foundation, ClavadelerstrasseDavosSwitzerland
  2. 2.Centre for Cell Engineering, Institute of Biomedical and Life SciencesJoseph Black Building, University of GlasgowGlasgowUnited Kingdom

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