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Journal of Materials Science: Materials in Medicine

, Volume 17, Issue 11, pp 1063–1068 | Cite as

Synthesis and sintering of biomimetic hydroxyapatite nanoparticles for biomedical applications

  • Suprabha Nayar
  • M. K. Sinha
  • D. Basu
  • Arvind Sinha
Article

Abstract

Synthesis of monodisperse nanoparticles with uniform morphology and narrow size distribution as achieved by nature is a challenge to materials scientists. Mimicking the process of biomineralization has led to the development of biomolecules mediated synthesis of nanoparticles that overcomes many of the problems associated with nanoparticle synthesis. Termed as biomimetics this paradigm shift in the philosophy of synthesis of materials is very advantageous for the design-based synthesis of nanoparticles. The effect of concentration of a protein named bovine serum albumin on particle size, morphology and degree of crystallinity of biomimetically synthesized hydroxyapatite particles, has been studied. Results establish 0.5% protein as the required concentration to produce 30–40 nm sized hydroxyapatite particles with an optimum degree of crystallinity as required for biomedical applications. These particles synthesized under certain stringent conditions are found to have stoichiometric calcium:phosphorus ratio of 1.67 and exhibit restricted grain growth during sintering.

Keywords

Apatite Crystal Bovine Serum Albumin Concentration Calcium Nitrate Tetrahydrate Bovine Serum Albumin Concen Adipamide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Suprabha Nayar
    • 1
  • M. K. Sinha
    • 2
  • D. Basu
    • 2
  • Arvind Sinha
    • 1
  1. 1.National Metallurgical LaboratoryJamshedpurIndia
  2. 2.Central Glass and Ceramic Research InstituteKolkataIndia

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