Synthesis and sintering of biomimetic hydroxyapatite nanoparticles for biomedical applications
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Synthesis of monodisperse nanoparticles with uniform morphology and narrow size distribution as achieved by nature is a challenge to materials scientists. Mimicking the process of biomineralization has led to the development of biomolecules mediated synthesis of nanoparticles that overcomes many of the problems associated with nanoparticle synthesis. Termed as biomimetics this paradigm shift in the philosophy of synthesis of materials is very advantageous for the design-based synthesis of nanoparticles. The effect of concentration of a protein named bovine serum albumin on particle size, morphology and degree of crystallinity of biomimetically synthesized hydroxyapatite particles, has been studied. Results establish 0.5% protein as the required concentration to produce 30–40 nm sized hydroxyapatite particles with an optimum degree of crystallinity as required for biomedical applications. These particles synthesized under certain stringent conditions are found to have stoichiometric calcium:phosphorus ratio of 1.67 and exhibit restricted grain growth during sintering.
KeywordsApatite Crystal Bovine Serum Albumin Concentration Calcium Nitrate Tetrahydrate Bovine Serum Albumin Concen Adipamide
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- 3.P. N. KUMTA, C. SFEIR, D. H. LEE, D. OLTON, D. CHOI, Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization, Acta Biomaterialia 1 (2005) 65.Google Scholar
- 11.S. MANN, DD ARCHIBALD, J. M. DIDYMUS, T. DOUGLAS, B. R. HEYWOOD, F. C. MELDRUM and N. J. REEVES, Crystallization at inorganic–organic interfaces: biominerals and biomimetic synthesis, Science 261 (1993) 1286.Google Scholar
- 13.A. SINHA, S. NAYAR, A. AGRAWAL, D. BHATTACHARYYA and P. RAMACHANDRARAO, Synthesis of nanosized and microporous precipitated hydroxyapatite in synthetic and biopolymers, J. Am Cer. Soc. 86 (2003) 357.Google Scholar
- 14.T. PETERS, Advances in Protein Chemistry (1985) 161.Google Scholar
- 17.K. FLADE, C. LAU, M. MERTIG and W. POMPE, Chem. Mater. 13(3) (2001) 596.Google Scholar