Skip to main content
SpringerLink
Log in

Surface modification of Ti45Nb alloy by immobilization of RGD peptide via self assembled monolayer

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

A new low modulus β Ti-Nb alloy with low elastic modulus and excellent corrosion resistance is currently under consideration as a surgical implant material. The usefulness of such materials can be dramatically enhanced if their surface structure and surface chemistry can be controlled. This control is achieved by attaching a self assembled monolayer (SAM) based on 11-chloroacetyl-1-undecylphosphonic acid, CAUDPA, to the surface and immobilization of a peptide to the monolayer. The SAM is characterized by Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Photoelectron Spectroscopy (XPS) at two different takeoff angles. The CAUDPA molecules were covalently bonded on the substrate in a configuration in which the phosphonic group turns toward the Ti45Nb while the acetyl chloride end group tail turns to the topmost surface. In such configuration sequential in situ reaction is possible by exchange between the chloride and a biological molecule. Such biological molecule is the arginine-glycine-aspartic acid-cysteine, RGDC, small amino acid sequence present in many molecules of the extracellular matrix. Preliminary cell culture in-vitro result shows an improvement of the response of osteoblast cells to Ti45Nb after the peptide immobilization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. M. NIINOMI, Biomaterials 24 (2003) 2673

    Article  CAS  Google Scholar 

  2. E. B. TADDEI, V. A. R. HENRIQUES, C. R. M. SILVA and C. A. A. CAIRO, Mater. Sci. Eng. C 24 (2004) 683

    Article  Google Scholar 

  3. R. GODLEY, D. STAROSVETSKY and I. GOTMAN, J. Mater. Sci: Mater. Med. 16 (2005) 1

    Article  Google Scholar 

  4. B. KASEMO, J Prosthet Dent 49 (1983) 832

    Article  CAS  Google Scholar 

  5. A. G. GRISTINA, Science 237 (1987) 1588

    Article  CAS  Google Scholar 

  6. E. RUOSLAHTI and M. D. PIERSCHBACHER, Science 238 (1987) 491

    Article  CAS  Google Scholar 

  7. D. M. FERIS, G. D. MOODIE, D. M. DIMOND, C. W. D. GIORANNI, M. G. ERLICH and R. F. VALENTINI, Biomaterials 20 (1999) 2323

    Article  Google Scholar 

  8. N. BALACHNDER and C. N. SUKENIK, Langmuir 6 (1990) 1621

    Article  Google Scholar 

  9. C. D. BAIN, E. B. TROUGHTON, Y. T. TAO, J. EVALL, G. M. WHITESIDES, R. G. NUZZO, J Am Chem Soc 111 (1989) 321

    Article  CAS  Google Scholar 

  10. L. H. DUBOIS and R. G. NUZZO, Ann. Rev. Phys. Chem. 43 (1992) 437

    CAS  Google Scholar 

  11. A. ULMAN, Chem. Rev. 96 (1996) 1533

    Article  CAS  Google Scholar 

  12. S. J. XIAO, M. TEXTOR and N. D. SPENCER, Langmuir 14 (1998) 5507

    Article  CAS  Google Scholar 

  13. E. S. GAWALT, M. J. AVALTRONI, M. P. DANAHY, B. M. SILVERMAN, E. L. HANSON, K. S. MIDWOOD, J. E. SCHWARZBAUER and J. SCHWARTZ, Langmuir 19 (2003) 200

    Article  CAS  Google Scholar 

  14. D. BROVELLI, G. HÄHNER, L. RUIZ, R. HOFER, G. KRAUS, A. WALDNER, J. SCHLÖSSER, P. OROSZLAN, M. EHART and N. D. SPENCER, Langmuir 15 (1999) 4324

    Article  CAS  Google Scholar 

  15. M. TEXTOR, L. RUIZ, R. HOFER, A. ROSSI, K. FELDMAN, G. HÄHNER and N. D. SPENCER, Langmuir 16 (2000) 3257

    Article  CAS  Google Scholar 

  16. J. L. FANG, N. J. WU, Z. W. WANG and Y. LI, Corrosion 47 (1991) 169

    CAS  Google Scholar 

  17. J. G. Van ALSTEN, Langmuir 15 (1999) 7605

    Article  Google Scholar 

  18. E. S. GAWALT, M. J. AVALTRONI, N. KOCH and J. SCHWARTZ, Langmuir 17 (2001) 5736

    Article  CAS  Google Scholar 

  19. J. LAUSMAA, B. KASEMO, H. MATTSSON and H. ODELIUS, App. Surf. Sci. 45 (1990) 189

    Article  CAS  Google Scholar 

  20. J. LAUSMAA, B. KASEMO, U. ROLANDER, L. M. BJURSTEN, L. E. ERICSON, L ROSANDER, P. THOMSEN, in “Surface Characterization of Biomaterials”, edited by B. D. Ratner (Elsevier, 1988) p. 161

  21. Y. SAHOO, H. PIZEM, T. FRIED, D. GOLODNITSKY, L. BURSTEIN, C. N. SUKENIK and G. MARKOVICH, Langmuir 17 (2001) 7907

    Article  CAS  Google Scholar 

  22. G. ZORN, I. GOTMAN, E. Y. GUTMANAS, R. ADADI, G. SALITRA and C. N. SUKENIK, Chem. Mater. 17 (2005) 4218

    Article  CAS  Google Scholar 

  23. S. TOSATTI, R. MICHEL, M. TEXTOR and N. D. SPENCER, Langmuir 18 (2002) 3537

    Article  CAS  Google Scholar 

  24. Y. WADA, H. KATAOKA, S. YOKOSE, T. ISHIZUYA, K. MIYAZONO, Y. -H. GAO, Y. SHIBASAKI and A. YAMAGUCHI, Bone 22 (1998) 479

    Article  CAS  Google Scholar 

  25. G. ZORN, A. LESMAN, I. GOTMAN, Surface Coat. Techn., (in press)

  26. H. YAMAMOTO, R. A. BUTERA, Y. GU and D. H. WALDECK, Langmuir 15 (1999) 8640

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors want to thank Dr. Reuven Brener from the Solid State Institute, Technion for his assistance in XPS analyses, and Dr. Anna Weiss from the Medical Faculty, Technion for cell culture preparation. We acknowledge the financial support of G.I.F. Research Grant N0 I-810-236.10/200, Commission of the European Communities, Network of Excellence EXCELL and of the Minerva Center for Tailored Biomaterial Interfaces at Bar Ilan University.

Author information

Authors and Affiliations

  1. Faculty of Materials Engineering, Technion, Haifa, Israel

    G. Zorn, I. Gotman & E. Y. Gutmanas

  2. Department of Chemistry, Bar-Ilan University, Ramat-Gan, Israel

    R. Adadi & C. N. Sukenik

Authors
  1. G. Zorn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Gotman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Y. Gutmanas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Adadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. N. Sukenik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to I. Gotman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zorn, G., Gotman, I., Gutmanas, E.Y. et al. Surface modification of Ti45Nb alloy by immobilization of RGD peptide via self assembled monolayer. J Mater Sci: Mater Med 18, 1309–1315 (2007). https://doi.org/10.1007/s10856-006-0117-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-006-0117-7

Keywords

Search

Navigation