Advertisement

Morphology and mechanical behavior of TTCP-derived calcium phosphate cement subcutaneously implanted in rats

  • C. H. Tsai
  • C. P. Ju
  • J. H. Chern Lin
Article

Abstract

A pre-hardened, TTCP-derived CPC was immersed in Hanks’ solution as well as subcutaneously implanted into abdomen of rats. The implant-soft tissue interfacial morphology was examined and properties of the CPC were evaluated and compared under in vitro and in vivo conditions. The results indicate that the surface of immersed samples appeared rougher and more porous than that of implanted samples and was covered with a layer of fine apatite crystals. The CPC samples implanted for 4 weeks or longer were surrounded by a layer of fibrous tissue, which was further surrounded by a soft tissue capsule comprising numerous fat cells. The soft tissue capsule had a non-uniform distribution in thickness, which increased most significantly between 4 weeks and 12 weeks after implantation. None of polymorphic cells, osteoblast cells or bone cells adjacent to the implant were observed. The majority of original TTCP powder was transformed into apatite after 1 day of either immersion in Hanks’ solution or implantation. The average porosity values of samples immersed in Hanks’ solution for 4 weeks or longer were significantly larger than those immersed for 1 day or 1 week. The porosity values of samples implanted for different times were not significantly different. The DTS values of Hanks’ solution-immersed samples largely decreased after a few weeks of immersion. The implanted samples maintained their strengths throughout the study.

Keywords

Calcium Phosphate Cement DCPA TTCP Capsule Thickness Polymorphic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    T. D. DRISKELL, A. L. HELLER and J. KOENIGS, US Patent 3913229 (1975)Google Scholar
  2. 2.
    W. E. BROWN and L. C. CHOW, J. Dent. Res. 82 (1983) 672Google Scholar
  3. 3.
    M. BOHNER, Injury 31 (2000) S-D37CrossRefGoogle Scholar
  4. 4.
    H. SCHLIEPHAKE, R. GRUBER, M. DARD, R. WENZ and S. SCHOLZ, J. Biomed. Mater. Res. 69A (2004) 382CrossRefGoogle Scholar
  5. 5.
    P. F. HEINI and U. BERLEMANN, Eur. Spine J. 10 (2001) S205CrossRefGoogle Scholar
  6. 6.
    B. R. CONSTANTZ, B. M. BARR, I. C. ISON, M. T. FULMER, J. BAKER, L. MCKINNEY, S. B. GOODMAN, S. GUNASEKAREN, D. C. DELANEY, J. ROSS and R. D. POSER, J. Biomed. Mater. Res Part B: Appl. Biomater. 43 (1998) 451CrossRefGoogle Scholar
  7. 7.
    J. M. KUEMMERLE, A. OBERLE, C. OECHSLIN, M. BOHNER, C. FREI, I. BOECKEN and B. VON RECHENBERG, J. Craniomaxillofac. Surg. 33 (2005) 37Google Scholar
  8. 8.
    E. M. OOMS, J. G. C. WOLKE and J. P. C. M. VAN DER WAERDEN and J. A. JANSEN, J. Biomed. Mater. Res. 61 (2002) 9CrossRefGoogle Scholar
  9. 9.
    K. KURASHINA, H. KURITA, A. KOTANI, S. KOBAYASHI, K. KYOSHIMA and M. HIARNO, Biomaterials 19 (1998) 701CrossRefGoogle Scholar
  10. 10.
    K. OHURA, M. BOHNER, P. HARDOUIN, J. LEMAITRE, G. PASQUIER and B. FLAUTRE, J. Biomed. Mater. Res. 30 (1996) 193CrossRefGoogle Scholar
  11. 11.
    G. DACULSI, N. PASSUTI, S. MARTIN, C. DEUDON and R. Z. LEGEROS, J. Biomed. Mater. Res. 24 (1990) 379CrossRefGoogle Scholar
  12. 12.
    G. DACULSI, P. WEISS, J. M. BOULER, O. GAUTHIER and E. AGUADO, Bone 25 (1999) 59SCrossRefGoogle Scholar
  13. 13.
    M. YOSHIKAWA and T. TODA, J. Eur. Ceram. Soc. 24 (2004) 521CrossRefGoogle Scholar
  14. 14.
    E. P. FRANKENBURG, S. A. GOLDSTEIN, T. W. BAUER, S. A. HARRIS and R. D. POSER, J. Bone Joint Surg. Am. 80 (1998) 1112Google Scholar
  15. 15.
    R. TAKEMASA and H. YAMAMOTO, in Proceedings of the NASS 17th Annual Meeting/The Spine J. 2 (2002) 96SGoogle Scholar
  16. 16.
    Y. MIYAMOTO, K. ISHIKAWA, M. TAKECHI, T. TOH, T. YUASA, M. NAGAYAMA and K. SUZUKI, J. Biomed. Mater. Res. 48 (1999) 36CrossRefGoogle Scholar
  17. 17.
    E. M. OOMS, E. A. EGGLEZOS, J. G. C. WOLKE and J. A. JANSEN, Biomaterials 24 (2003) 749CrossRefGoogle Scholar
  18. 18.
    Z. YANG, H. YUAN, W. TONG, P. ZOU, W. CHEN and X. ZHANG, Biomaterials 17 (1996) 2131CrossRefGoogle Scholar
  19. 19.
    H. YUAN, Y. LI, J. D. DE BRUIJN, K. DE GROOT and X. ZHANG, Biomaterials 21 (2000) 1283CrossRefGoogle Scholar
  20. 20.
    I. C. WANG, J. H. CHERN LIN and C. P. JU, Mater. Trans. JIM 46(4) (2005) 885CrossRefGoogle Scholar
  21. 21.
    D. C. MEARS, Int. Mater. Rev. 22 (1977) 119Google Scholar
  22. 22.
    R. G. ERBEN, J. Histochem. Cytochem. 45(2) (1997) 307Google Scholar
  23. 23.
    B. D. RATNER, A. S. HOFFMAN, F. J. SCHOEN, J. E. LEMONS, in “Biomaterials Science” (Academic, California, 1996) p. 222Google Scholar
  24. 24.
    J. BARALET, M. AKAO, H. AOKI and H. AOKI, J. Biomed. Mater. Res. 49 (2000) 176CrossRefGoogle Scholar
  25. 25.
    J. A. SZIVEK, A. G. BATTRAW, S. PERSSELIN and P. L. ANDERSON, J. Biomed. Mater. Res. Part B: Appl. Biomater. 53 (2000) 211CrossRefGoogle Scholar
  26. 26.
    W. C. CHEN, J. H. CHERN LIN and C. P. JU, J. Biomed. Mater. Res. 64A(4) (2003) 664CrossRefGoogle Scholar
  27. 27.
    E. FERNÁNDEZ, in “Wiley Encyclopedia of Biomedical Engineering” (John Wiley & Sons, Inc., 2006) vol. 6Google Scholar
  28. 28.
    S. SARDA, E. FERNÁNDEZ, M. NILSSON, M. BALCELLS and J. A. PLANELL, J. Biomed. Mater. Res. 61 (2002) 653CrossRefGoogle Scholar
  29. 29.
    E. FERNÁNDEZ, M. P. GINEBRA, M. G. BOLTONG, F. C. DRIESSENS, J. GINEBRA, E. A. DE MAEYER, R. M. VERBEECK and J. A. PLANELL, J. Biomed. Mater. Res. 32 (1996) 367CrossRefGoogle Scholar
  30. 30.
    K. L. LIN, C. P. JU and J. H. CHERN LIN, J. Mater. Sci. 40 (2005) 2631CrossRefGoogle Scholar
  31. 31.
    W. C. CHEN, C. P. JU and J. H. CHERN LIN, J. Oral Rehabil. 34 (2007) 541CrossRefGoogle Scholar
  32. 32.
    D. KNAACK, M. E. P. GOAD, M. AIOLOVA, C. REY, A. TOFIGHI, P. CHAKRAVARTHY and D. D. LEE, J. Biomed. Mater. Res. Part B: Appl. Biomater. 43 (1998) 399CrossRefGoogle Scholar
  33. 33.
    D. M. LIU, Q. YANG, T. TROCZYNSKI and W. J. TSENG, Biomaterials 23 (2002) 1679CrossRefGoogle Scholar
  34. 34.
    H. YAMAMOTO, S. NIWA, M. HORI, T. HATTORI, K. SAWAI, S. AOKI, M. HIRANO and H. TAKEUCHI, Biomaterials 19 (1998) 1587CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Materials Science and EngineeringNational Cheng-Kung UniversityTainanTaiwan, ROC

Personalised recommendations