Abstract
A new class of materials based on inorganic and organic species combined at a nanoscale level has received large attention recently. In this work the idea of producing hybrid materials with controllable properties is applied to obtain foams to be used as scaffolds for tissue engineering. Hybrids were synthesized by reacting poly(vinyl alcohol) in acidic solution with tetraethylorthosilicate. The inorganic phase was also modified by incorporating a calcium compound. Hydrated calcium chloride was used as precursor. A surfactant was added and a foam was produced by vigorous agitation, which was cast just before the gel point. Hydrofluoric acid solution was added in order to catalyze the gelation. The foamed hybrids were aged at 40 ∘C and vacuum dried at 40 ∘C. The hybrid foams were analyzed by Scanning Electron Microscopy, Mercury Porosimetry, Nitrogen Adsorption, X-ray Diffraction and Infra-red Spectroscopy. The mechanical behavior was evaluated by compression tests. The foams obtained had a high porosity varying from 60 to 90% and the macropore diameter ranged from 30 to 500 μ m. The modal macropore diameter varied with the inorganic phase composition and with the polymer content in the hybrid. The surface area and mesopore volume decreased as polymer concentration increased in the hybrids. The strain at fracture of the hybrid foams was substantially greater than pure gel-glass foams.
Similar content being viewed by others
References
H. J. BREKKE and M. J. TOTHMJ, J. Biomed. Mater. Res. 43 (1998) 380.
A. H. REDDI, Tissue Engng. 6 (2000) 351.
R. A. J. FELICITY and R. O. C. OREFFO, Biochem. Biophys. Res. Commun. 292 (2002) 1.
S. H. LI, J. R. DE WIJN, P. LAYROLLE and K. DE GROOT, J. Biomed. Mater. Res. 61 (2002) 109.
J. DONG, T. UEMURA, Y. SHIRASAKI and T. TATEISHI, Biomaterials 23 (2002) 4493.
P. SEPULVEDA, J. R. JONES and L. L. HENCH, J. Biomed. Mater. Res. 59 (2002) 340.
F. MONCHAU, A. LEFEVRE, M. DESCAMPS, A. BELQUIN-MYRDYCS, P. LAFFARGUE and H. F. HILDEBRAND, Biomol. Engng. 19 (2002) 143.
L. L. HENCH, J. M. POLAK, I. D. XYNOS and L. D. K BUTTERY, Mat. Res. Inn. 3 (2000) 313.
I. D. XYNOS, A. J. EDGAR, L. D. K. BUTTERY, L. L. HENCH and J. M. POLAK, Biochem. Biophys. Res. Comm. 276 (2000) 461.
D. M. REFFITT, N. OGSTON, R. JUGDAOHSINGH, H. F. J. CHEUNG, B. A. J. EVANS, R. P. H. THOMPSON, J. J. POWELL and G. N. HAMPSON, Bone 32 (2003) 127.
C. M. BOTELHO, R. A. BROOKS, S. M. BEST, M. A. LOPES, J. D. SANTOS, N. RUSHON and W. BONFIELD, Key Engng. Mater. 254–256 (2004) 845.
N. PATEL, S. M. BEST, W. BONFIELD, I. R. GIBSON, K. A. HING, A. DAMIEN and P. A. REVELL, J. Biomed. Mater. Res. Mater Med. 13 (2002) 1199.
C. M. AGRAWAL and R. B. RAY, J. Biomed. Mater. Res. 55 (2001) 141.
J. M. TABOAS, R. D. MADDOX, P. H. KREBSBACH and S. J. HOLLISTER, Biomaterials 24 (2003) 181.
J. A. ROETHER, A. R. BOCCACCINI, L. L. HENCH, V. MAQUET, S. GAUTIER and R. JÉROME, ibid. 23 (2002) 3871.
A. B. BRENNAN and T. M. MILLER, in “Kirk-Othmer Encyclopedia of Chemical Technology” (John Wiley & Sons Inc., 1994) p. 644.
M. KAMITAKAHARA, M. KAWASHITA and N. MIYATA, J. Sol-Gel Sci. Tech. 21 (2001) 75.
P. BOSCH, F. DEL MONTE, J. L. MATEO and D. LEVY, J. Polym. Sci. A Polym. Chem. 34 (1996) 3289.
Z. H. HUANG and K. Y. QIU, Polymer 38 (1997) 521.
M. B. COELHO, I. R. SOARES, H. S. MANSUR and M. M. PEREIRA, Key Engng. Mater. 240–242 (2003) 257.
J. R. JONES and L. L. HENCH, J. Mater. Sci. 38 (2003) 3783.
S. H. RHEE, J. Y. CHOI and H. M. KIM, Biomaterials 23 (2002) 4915.
J. M. YANG, C. S. LU, Y. G. HSU and C. H. SHIH, J. Biomed. Mater. Res. 38 (1997) 143.
Q. CHEN, N. MIYATA, T. KOKUBO and T. NAKAMURA, ibid. 51 (2000) 605.
P. BOSCH, F. DEL MONTE, J. L. MATEO and D. LEVY, J. Polym. Sci. A Polym. Chem. 34 (1996) 3289.
Z. H. HUANG and K. Y. QIU, Polymer 38 (1997) 521.
P. HAJJI, L. DAVID and J. F. GERARD, J. Polym. Sci. B: Polym. Phys. 37 (1999) 3172.
F. SUZUKI, K. ONOZATO and Y. KUROKAWA, J. Appl. Pol. Sci. 39 (1990) 371.
R. VON KLITZING and H. J. MULLER, Curr. Opin. Coll. Interf. Sci. 7 (2002) 42.
R. M. ALMEIDA and C. G. PANTANO, J. Appl. Phys. 68 (1990) 4225.
D. A. SKOOG and J. J. LEARY, “Principles of Instrumental Analysis” (Saunders College Publishing, 1992).
D. KLEE and H. HÖOCKER, Adv. Polym. Sci. 149 (2000) 1.
J. S. REED, “Principles of Ceramic Processing” (John Wiley & Sons, 1995).
M. M. PEREIRA, N. AL-SAFFAR, J. SELVAKUMARAN and L. L. HENCH, Key Eng. Mater. 284–286 (2005) 589.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pereira, M.M., Jones, J.R., Orefice, R.L. et al. Preparation of bioactive glass-polyvinyl alcohol hybrid foams by the sol-gel method. J Mater Sci: Mater Med 16, 1045–1050 (2005). https://doi.org/10.1007/s10856-005-4758-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10856-005-4758-8