Physical and in vitro evaluation of ultra-fine cohenite particles for the prospective magnetic hyperthermia application

Abstract

We report here the structural and biocompatibility studies of bare nanoparticles of θ-Fe3C and its ferrofluid, prepared using pluronic acid F127 as a stabilizer. For both the cases, this carbide was compatible (~ 80% cell viability after 48 h) with A549 human lung carcinoma cells up to a concentration of 2 mg/mL which was comparable to that of its magnetic iron oxide counterparts. The X-ray diffraction and transmission electron microscopy validated its orthorhombic phase having an average particle size of ~ 6 nm. The surface property of the θ-Fe3C sample was analyzed by X-ray photoelectron spectroscopy (XPS), which designates the existence of only Fe and C. The Mössbauer spectroscopy for the sample also verified this carbide phase. The room temperature saturation magnetization for the sample at 2 T was around 78.2 Am2/kg. This value was more than that of magnetic iron oxide nanoparticles of similar size. Its ferrofluid displayed substantial temperature rise with time during the magnetic hyperthermia experiment. Consequently, the obtained specific loss power, as well as intrinsic loss power values, were 46 W/g and 0.526 nHm2/kg, respectively, at a field of 23 mT and 261 kHz. Both the values indicated its suitability for magnetic hyperthermia application.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

References

  1. 1.

    N.K. Prasad, D. Panda, S. Singh, M.D. Mukadam, S.M. Yusuf, D. Bahadur, J. Appl. Phys. 97, 97–100 (2005)

    Article  CAS  Google Scholar 

  2. 2.

    M. Sharma, S. Mantri, D. Bahadur, J. Magn. Magn. Mater. 324, 3975–3980 (2012)

    CAS  Article  Google Scholar 

  3. 3.

    N. Shahabadia, A. Akbaric, M. Jamshidbeigic, M. Falsafi, J. Mol. Liq. 224, 227–233 (2016)

    Article  CAS  Google Scholar 

  4. 4.

    S.V. Jadhav, P.S. Shewale, B.C. Shin, M.P. Patil, G.D. Kim, A.A. Rokade, S.S. Park, R.A. Bohara, J. Colloid Interface Sci. 541, 192–203 (2019)

    CAS  Article  Google Scholar 

  5. 5.

    J.K. Oh, J.M. Park, Prog. Polym. Sci. 36, 168–189 (2011)

    CAS  Article  Google Scholar 

  6. 6.

    K.K. Narayanasamy, M.C. Acuña, C. Rinaldi, J. Everett, J. Dobson, N.D. Telling, J. Colloid Interface Sci. 532, 536–545 (2018)

    CAS  Article  Google Scholar 

  7. 7.

    B. Sanz, M.P. Calatayud, T.E. Torres, M.L. Fanarraga, M.R. Ibarra, G.F. Goya, Biomaterials 114, 62–70 (2017)

    CAS  Article  Google Scholar 

  8. 8.

    C. Prasad, K. Sreenivasulu, S. Gangadhara, P. Venkateswarlu, J. Mol. Liq. 221, 993–998 (2016)

    Article  CAS  Google Scholar 

  9. 9.

    S. Nigam, K.C. Barick, D. Bahadur, J. Magn. Magn. Mater. 323, 237–243 (2011)

    CAS  Article  Google Scholar 

  10. 10.

    P. Priyananda, H. Sabouri, N. Jain, B.S. Hawkett, Langmuir 34, 3068–3075 (2018)

    CAS  Article  Google Scholar 

  11. 11.

    A. Gangwar, S.K. Alla, M. Srivastava, S.S. Meena, E.V. Prasadrao, R.K. Mandal, S.M. Yusuf, N.K. Prasad, J. Magn. Magn. Mater. 401, 559–566 (2016)

    CAS  Article  Google Scholar 

  12. 12.

    B.K. Barman, K.K. Nanda, Green Chem. 18, 427–432 (2016)

    CAS  Article  Google Scholar 

  13. 13.

    Z. Karimi, L. Karimi, H. Shokrollahi, Mater. Sci. Eng. C 33, 2465–2475 (2013)

    CAS  Article  Google Scholar 

  14. 14.

    V. Arora, A. Sood, J. Shah, R.K. Kotnala, T.K. Jain, Mater. Chem. Phys. 173, 161–167 (2016)

    CAS  Article  Google Scholar 

  15. 15.

    A. Sood, V. Arora, J. Shah, R.K. Kotnala, T.K. Jain, J. Exp. Sci. 11, 370–382 (2016)

    CAS  Google Scholar 

  16. 16.

    M. A. Malvindi, V. D. Matteis, A. Galeone, V. Brunetti, G. C. Anyfantis, A. Athanassiou, R. Cingolani, P.P. Pompa, PLoS one 9, 1–11

  17. 17.

    S. Odenbach, J. Magn. Magn. Mater. 170, 309–316 (1997)

    CAS  Article  Google Scholar 

  18. 18.

    Z. Tsai, F. Tsai, W. Yang, J. Wang, C. Liu, C. Shen, T. Yen, Mar. Drugs 10, 2403–2414 (2012)

    CAS  Article  Google Scholar 

  19. 19.

    J. Liu, Y. Bowen, Z. Qiankun, H. Lizhen, H. Qiulai, S. Chunrui, W. Shiliang, W. Yueqin, H. Yuehui, Z. Jin, H. Han, Nanotechnology 26, 115–121 (2015)

    Google Scholar 

  20. 20.

    Q.A. Pankhurst, J. Connolly, S.K. Jones, J. Dobson, J. Phys. D 36, R167–R181 (2003)

    CAS  Article  Google Scholar 

  21. 21.

    B. David, O. Schneeweiss, M. Mashlan, E. Šantavá, I. Morjan, J. Magn. Magn. Mater. 316, 422–425 (2007)

    CAS  Article  Google Scholar 

  22. 22.

    S. Kossatz, J. Grandke, P. Couleaud, A. Latorre, A. Aires, K.C. Staunton, R. Ludwig, H. Dähring, V. Ettelt, Breast Cancer Res. 17, 1–17 (2015)

    CAS  Article  Google Scholar 

  23. 23.

    T. Kobayashi, K. Kakimi, E. Nakayama, K. Jimbow, Nanomedicine 9, 1715–1726 (2014)

    CAS  Article  Google Scholar 

  24. 24.

    A. Gangwar, G. Singh, S.K. Shaw, R.K. Mandal, A. Sharma, S.S. Meena, C.L. Prajapat, N.K. Prasad, New J. Chem. 43, 3536–3544 (2019)

    CAS  Article  Google Scholar 

  25. 25.

    X. Wang, Z. Daguang, R. Xiaozhen, J. Gao, H. Yu, C. Xiaodong, S. Zhan, H. Yang, J. Magn. Magn. Mater. 420, 241–244 (2016)

    CAS  Article  Google Scholar 

  26. 26.

    X.Q. Zhao, Y. Liang, Z.Q. Hu, B.X. Liu, J. Appl. Phys. 80, 5857–5860 (1996)

    CAS  Article  Google Scholar 

  27. 27.

    H. Silva, E. Lima, M.V. Mansilla, R.D. Zysler, H. Troiani, M.L.M. Pisciotti, C. Locatelli, J.C. Benech, N. Oddone, V.C. Zoldan, E. Winter, A.A. Pasa, T.B.C. Pasa, Nanomed. Nanotechnol. Biol. Med. 12, 909–919 (2016)

    CAS  Article  Google Scholar 

  28. 28.

    N.K. Prasad, M. Srivastava, S.K. Alla, J.R. Danda, D. Aditya, R.K. Mandal, RSC Adv. 47, 41268–41274 (2016)

    Article  CAS  Google Scholar 

  29. 29.

    Y.M. Huh, Y.W. Jun, H.T. Song, S. Kim, J.S. Choi, J.H. Lee, S. Yoon, K.S. Kim, J.S. Shin, J.S. Suh, J. Cheon, J. Am. Chem. Soc. 127, 12387–12391 (2005)

    CAS  Article  Google Scholar 

  30. 30.

    R. Alexandrescu, I. Morjan, F. Dumitrache, R. Birjega, C. Jaeger, H. Mutschke, I. Soare, L. Gavrila-Florescu, V. Ciupina, Mater. Sci. Eng. C 27, 1181–1184 (2007)

    CAS  Article  Google Scholar 

  31. 31.

    Y. Jiang, X. Fu, Z. Zhang, W. Du, P. Xie, C. Chang, R. Fan, J. Alloys Compd. 313, 804305 (2019)

    Google Scholar 

  32. 32.

    G. Fan, Y. Jiang, J. Xin, Z. Zhang, X. Fu, P. Xie, C. Cheng, Y. Liu, Y. Qu, K. Sun, R. Fan, A.C.S. Sustain, Chem. Eng. 7, 18765–187774 (2019)

    CAS  Google Scholar 

  33. 33.

    Q. Su, G. Zhong, J. Li, G. Du, B. Xu, Appl. Phys. A 106, 59–65 (2012)

    CAS  Article  Google Scholar 

  34. 34.

    W. Zhou, Y. Yu, X. Xiong, S. Zhou, Materials 11, 878–888 (2018)

    Article  CAS  Google Scholar 

  35. 35.

    K.C. Barick, S. Singh, D. Bahadur, M.A. Lawande, D.P. Patkar, P.A. Hassan, J. Colloid Interface Sci. 418, 120–125 (2014)

    CAS  Article  Google Scholar 

  36. 36.

    X.W. Liu, Z. Cao, S. Zhao, R. Gao, Y. Meng, J.X. Zhu, C. Rogers, C.F. Huo, Y. Yang, Y.W. Li, X.D. Wen, J. Phys. Chem. C 121, 211–230 (2017)

    Article  CAS  Google Scholar 

  37. 37.

    K. Cheng, V.V. Ordomsky, M. Virginie, B. Legras, P.A. Chernavskii, V.O. Kazak, C. Cordier, S. Paul, Y. Wang, A.Y. Khodakov, Appl. Catal. A 488, 66–77 (2014)

    CAS  Article  Google Scholar 

  38. 38.

    G. Schinteie, V. Kuncser, P. Palade, F. Dumitrache, R. Alexandrescu, I. Morjan, G. Filoti, J. Alloys Compd. 564, 27–34 (2013)

    CAS  Article  Google Scholar 

  39. 39.

    S. Ye, Y. Cao, Int. Conf. AMITP 13, 6–9 (2016)

    Google Scholar 

  40. 40.

    I. Morjan, R. Alexandrescu, M. Scarisoreanu, C. Fleaca, F. Dumitrache, I. Soare, E. Popovici, L. Gavrila, E. Vasile, V. Ciupina, N.C. Popa, Appl. Surf. Sci. 255, 9638–9642 (2009)

    CAS  Article  Google Scholar 

  41. 41.

    G. Kandasamy, A. Sudame, P. Bhati, A. Chakrabarty, D. Maity, J. Mol. Liq. 256, 224237 (2018)

    Article  CAS  Google Scholar 

  42. 42.

    M. Yu, S. Huang, K.J. Yu, A.M. Clyne, Int. J. Mol. Sci. 10, 1022–1030 (2012)

    Google Scholar 

  43. 43.

    X. Wang, P. Zhang, W. Wang, X. Lei, H. Yang, J. Alloys Compd. 683, 450–455 (2016)

    CAS  Article  Google Scholar 

  44. 44.

    M. Srivastava, S.K. Alla, S. Meena, N.K. Prasad, New. J. Chem. 7, 7144–7153 (2018)

    Article  Google Scholar 

  45. 45.

    R. Kumar, H.K. Choudhary, S.P. Pawar, S. Bose, B. Sahoo, Phys. Chem. Chem. Phys. 19, 23268–23279 (2017)

    CAS  Article  Google Scholar 

  46. 46.

    R. Snovski, J. Grinblat, M.T. Sougrati, J.C. Jumas, S. Margel, J. Magn. Magn. Mater. 349, 35–44 (2014)

    CAS  Article  Google Scholar 

  47. 47.

    A. Gangwar, S.S. Varghese, S.S. Meena, C.L. Prajapat, N. Gupta, N.K. Prasad, J. Magn. Magn. Mater. 481, 251–256 (2019)

    CAS  Article  Google Scholar 

  48. 48.

    N.S. Kopelev, V. Chechersky, A. Nath, Z.L. Wang, E. Kuzmann, B. Zhang, H. Grayson, Chem. Mater. 7, 1419–1421 (1995)

    CAS  Article  Google Scholar 

  49. 49.

    B. Kniep, A. Constantinescu, D. Niemeier, K.D. Becker, Zeitschrift fur Anorg. und Allg Chemie. 629, 1795–1804 (2003)

    CAS  Article  Google Scholar 

  50. 50.

    J.J. Lin, J.S. Chen, S.J. Huang, J.H. Ko, Y.M. Wang, T.L. Chen, L.F. Wang, Biomaterials 30, 5114–5124 (2009)

    CAS  Article  Google Scholar 

  51. 51.

    M. Gonzales, K.M. Krishnan, J. Magn. Magn. Mater. 311, 59–62 (2007)

    CAS  Article  Google Scholar 

  52. 52.

    M. Srivastava, S.S. Meena, R.K. Mandal, S.M. Yusuf, N.K. Prasad, J. Alloys Compd. 42, 7144–7153 (2016)

    Google Scholar 

  53. 53.

    R. Yasemian, M.A. Kashi, A. Ramazani, Mater. Chem. Phys. 230, 9–16 (2019)

    CAS  Article  Google Scholar 

  54. 54.

    S.A. Shah, A. Majeed, K. Rashid, S.U. Awan, Mater. Chem. Phys. 138, 703–708 (2013)

    CAS  Article  Google Scholar 

  55. 55.

    A. Gangwar, S. Kumar, S.S. Meena, A. Sharma, M.K. Viswanadh, K. Neogi, M.S. Muthu, N.K. Prasad, Appl. Surf. Sci. 509, 144891 (2020)

    Article  CAS  Google Scholar 

  56. 56.

    B. Ankamwar, T.C. Lai, J.H. Huang, R.S. Liu, M. Hsiao, C.H. Chen, Y.K. Hwu, Nanotechnology 21, 075102 (2010)

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to N. K. Prasad.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gangwar, A., Varghese, S.S., Meena, S.S. et al. Physical and in vitro evaluation of ultra-fine cohenite particles for the prospective magnetic hyperthermia application. J Mater Sci: Mater Electron 31, 10772–10782 (2020). https://doi.org/10.1007/s10854-020-03628-9

Download citation