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Synthesis and characterization of hydrogels based on poly(2-hydroxyethyl methacrylate) for drug delivery under UV irradiation

  • Biomaterials
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Abstract

The present study aims to create a controlled release system through the preparation and characterization of hydrogels based on 2-hydroxyl ethyl methacrylate (HEMA). In order to investigate the influence of photo-initiators on the drug release behavior of the resulting hydrogels, three different photo-initiators [2,2-dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1-hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used. In addition, hydroxyapatite (HAp) was employed to modify HEMA hydrogels. The synthesis of hydrogels was confirmed by characterization through Fourier transform infrared spectroscopy, nuclear magnetic resonance (13C NMR) spectroscopy and digital microscope. The responsive behaviors were investigated by recording swelling ratios under different conditions. In vitro drug release studies were performed for donepezil hydrochloride-loaded hydrogels at pH 1.2, 6.8 and 7.4. The results indicated that hydrogels synthesized using Irgacure 2959 released the maximum amount of donepezil hydrochloride. Moreover, the release rate decreased in the presence of HAp.

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Acknowledgements

This work was supported by Research Fund of the Yildiz Technical University. Project Number: FDK-2017-3029.

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Authors and Affiliations

  1. Department of Chemical Engineering, Yildiz Technical University, 34210, Istanbul, Turkey

    Sebnem Senol & Emel Akyol

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  1. Sebnem Senol
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  2. Emel Akyol
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Correspondence to Emel Akyol.

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Senol, S., Akyol, E. Synthesis and characterization of hydrogels based on poly(2-hydroxyethyl methacrylate) for drug delivery under UV irradiation. J Mater Sci 53, 14953–14963 (2018). https://doi.org/10.1007/s10853-018-2713-6

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  • DOI: https://doi.org/10.1007/s10853-018-2713-6

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