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Bacterial cell killing properties of silver-loaded polysiloxane microspheres

  • Biomaterials
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Abstract

Cross-linked polysiloxane microspheres containing a large number of SiOH groups were modified by introduction of organic thiol groups, which were further used for the functionalization of the microspheres with silver thiolate groups. The microspheres were characterized by 29Si MAS NMR, 13C MAS NMR, SEM, XPS and elemental analysis. They were tested as biocides against selected Gram-positive and Gram-negative bacteria strains and exhibited high bactericidal activity. Separately, linear polysiloxane polymers equipped with organothiol groups and loaded with silver were synthesized. Their antibacterial activity was compared with that of silver thiolate-functionalized microspheres. Different shape of particles and a different form of silver explained somewhat lower activity of polymers.

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Acknowledgements

The authors are grateful to Professor Hieronim Maciejewski from Poznan Science and Technology Park of Adam Mickiewicz University Foundation for kind offer of (3-mercaptopropyl)dimethylmethoxysilane and to Nicholas Beaumont for the improvement in language.

Funding

This study was funded by the Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences and the Gdansk Medical University.

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Authors and Affiliations

  1. Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicz Str. 112, 90-363, Lodz, Poland

    Urszula Mizerska, Julian Chojnowski, Piotr Pospiech, Witold Fortuniak, Stanislaw Slomkowski, Tomasz Makowski & Przemyslaw Sowinski

  2. Chair and Department of Pharmaceutical Microbiology, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland

    Rafal Halasa & Katarzyna Turecka

  3. Department of Material and Commodity Sciences and Textile Metrology, Lodz University of Technology, Zeromski Str. 116, Lodz, Poland

    Waldemar Machnowski

Authors
  1. Urszula Mizerska
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  2. Rafal Halasa
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  3. Katarzyna Turecka
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  4. Julian Chojnowski
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  5. Piotr Pospiech
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  6. Witold Fortuniak
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  7. Stanislaw Slomkowski
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  8. Tomasz Makowski
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  9. Waldemar Machnowski
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  10. Przemyslaw Sowinski
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Correspondence to Urszula Mizerska.

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Mizerska, U., Halasa, R., Turecka, K. et al. Bacterial cell killing properties of silver-loaded polysiloxane microspheres. J Mater Sci 53, 7125–7137 (2018). https://doi.org/10.1007/s10853-018-2084-z

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  • DOI: https://doi.org/10.1007/s10853-018-2084-z

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