Bacterial cell killing properties of silver-loaded polysiloxane microspheres
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Cross-linked polysiloxane microspheres containing a large number of SiOH groups were modified by introduction of organic thiol groups, which were further used for the functionalization of the microspheres with silver thiolate groups. The microspheres were characterized by 29Si MAS NMR, 13C MAS NMR, SEM, XPS and elemental analysis. They were tested as biocides against selected Gram-positive and Gram-negative bacteria strains and exhibited high bactericidal activity. Separately, linear polysiloxane polymers equipped with organothiol groups and loaded with silver were synthesized. Their antibacterial activity was compared with that of silver thiolate-functionalized microspheres. Different shape of particles and a different form of silver explained somewhat lower activity of polymers.
The authors are grateful to Professor Hieronim Maciejewski from Poznan Science and Technology Park of Adam Mickiewicz University Foundation for kind offer of (3-mercaptopropyl)dimethylmethoxysilane and to Nicholas Beaumont for the improvement in language.
This study was funded by the Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences and the Gdansk Medical University.
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Conflict of interest
The authors declare that they have no conflict of interest.
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