Journal of Materials Science

, Volume 50, Issue 18, pp 6208–6219 | Cite as

Evaluation of poly(hydroxyethyl acrylate/itaconic acid) hydrogels for controlled delivery of transition metal complexes with Oxaprozin as potential antiproliferative agents

  • Marija M. Babić
  • Bojan Đ. Božić
  • Biljana Đ. Božić
  • Jovanka M. Filipović
  • Gordana S. Ušćumlić
  • Simonida Lj. Tomić
Original Paper


A series of dual-sensitive poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)) hydrogels were synthesized and evaluated as drug delivery systems for potential antiproliferative agents. Investigated hydrophobic compounds, Mn(II) and Zn(II) complexes with Oxaprozin, were efficiently loaded into the P(HEA/IA) hydrogels, which was confirmed by FTIR and UV–Vis spectroscopy. Swelling studies, conducted in the physiological pH range of 2.20–8.00 and in temperature range of 30–50 °C, demonstrated that loaded transition metal complexes in P(HEA/IA) hydrogels did not annul pH and temperature sensitivity of the hydrogels. In vitro antiproliferative activity of Mn(II) and Zn(II) complexes with Oxaprozin against human cervical (HeLa) and melanoma cancer (Fem X) cell lines was tested. Results of in vitro release study investigated at different pH conditions confirmed P(HEA/IA) hydrogels as a highly effective pH-triggered drug delivery system for hydrophobic antiproliferative agents. These performances indicate that P(HEA/IA) hydrogels loaded with transition metal complexes can be further studied as a promising candidate for anticancer therapy, as well as for targeted treatment of intestine/colon cancers.


Drug Loading Transition Metal Complex Entrapment Efficiency Itaconic Acid Oxaprozin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work has been supported by the Ministry for Education, Science and Technological Development of the Republic of Serbia (Grants No. 172062 and 172013).


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Marija M. Babić
    • 1
  • Bojan Đ. Božić
    • 1
  • Biljana Đ. Božić
    • 2
  • Jovanka M. Filipović
    • 1
  • Gordana S. Ušćumlić
    • 1
  • Simonida Lj. Tomić
    • 1
  1. 1.Faculty of Technology and MetallurgyUniversity of BelgradeBelgradeSerbia
  2. 2.Faculty of BiologyUniversity of BelgradeBelgradeSerbia

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