Evaluation of poly(hydroxyethyl acrylate/itaconic acid) hydrogels for controlled delivery of transition metal complexes with Oxaprozin as potential antiproliferative agents
- 303 Downloads
A series of dual-sensitive poly(2-hydroxyethyl acrylate/itaconic acid) (P(HEA/IA)) hydrogels were synthesized and evaluated as drug delivery systems for potential antiproliferative agents. Investigated hydrophobic compounds, Mn(II) and Zn(II) complexes with Oxaprozin, were efficiently loaded into the P(HEA/IA) hydrogels, which was confirmed by FTIR and UV–Vis spectroscopy. Swelling studies, conducted in the physiological pH range of 2.20–8.00 and in temperature range of 30–50 °C, demonstrated that loaded transition metal complexes in P(HEA/IA) hydrogels did not annul pH and temperature sensitivity of the hydrogels. In vitro antiproliferative activity of Mn(II) and Zn(II) complexes with Oxaprozin against human cervical (HeLa) and melanoma cancer (Fem X) cell lines was tested. Results of in vitro release study investigated at different pH conditions confirmed P(HEA/IA) hydrogels as a highly effective pH-triggered drug delivery system for hydrophobic antiproliferative agents. These performances indicate that P(HEA/IA) hydrogels loaded with transition metal complexes can be further studied as a promising candidate for anticancer therapy, as well as for targeted treatment of intestine/colon cancers.
KeywordsDrug Loading Transition Metal Complex Entrapment Efficiency Itaconic Acid Oxaprozin
This work has been supported by the Ministry for Education, Science and Technological Development of the Republic of Serbia (Grants No. 172062 and 172013).
- 3.Choedon T, Mathan G, Arya S, Kumar VL, Kumar V (2006) Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma. World J Gastroeterol 12:2517–2522Google Scholar
- 7.Rafique S, Idrees M, Nasim A, Akbar H, Athar A (2010) Transition metal complexes as potential therapeutic agents. Biotechnol Mol Biol Rev 5:38–45Google Scholar
- 9.Iizuka Y, Sakurai E, Tanaka Y (2001) Effects of trace element deficiency on drug metabolizing enzymes in rats. Riken Rev 35:3–4Google Scholar
- 10.Lippard SJ, Berg JM (1994) Principles of bioinorganic chemistry. University Science Books, Mill ValleyGoogle Scholar
- 13.Baron JA (2003) Epidemiology of non-steroidal anti-inflammatory drugs and cancer. Prog Exp Tumor Res 37:1–24Google Scholar
- 15.Lay P Hambley T, (2007) WO Patent 109843 2007Google Scholar
- 17.Babić MM, Antić KM, Vuković JSJ, Božić BĐ, Davidović SZ, Filipović JM, Tomić SLj (2015) Oxaprozin/poly(2-hydroxyethyl acrylate/itaconic acid) hydrogels: morphological, thermal, swelling, drug release and antibacterial properties. J Mater Sci 50:906–922. doi: 10.1007/s10853-014-8651z CrossRefGoogle Scholar
- 18.Brown K (1971) Oxazoles, US patent 3,578,671Google Scholar
- 20.Peppas NA (1985) Analysis of Fickian and non-Fickian drug release from polymer. Pharm Acta Helv 60:110–111Google Scholar