Journal of Materials Science

, Volume 50, Issue 14, pp 4898–4913 | Cite as

Stable antifouling coatings by hydrogen-bonding interaction between poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) and poly(acrylic acid)

  • Lin Tan
  • Longchao Bai
  • Haikun Zhu
  • Chong Zhang
  • Lijuan Chen
  • Yanmei Wang
  • Hervé Cheradame
Original Paper


Surface modified with so-called protein-repellent or antifouling polymers has become indispensable for the development of modern therapeutic and diagnostic medical devices. In this work, a series of novel well-defined poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) (PMOXA-b-P4VP) diblock copolymers were synthesized by using copper-catalyzed azide-alkyne cycloaddition reaction of α-alkynyl-PMOXA and ω-N3-P4VP, in which α-alkynyl-PMOXA and ω-N3-P4VP were prepared by cationic ring opening polymerization and atom transfer radical polymerization, respectively. Stable coatings were formed when dropping PAA solution on the top of PMOXA-b-P4VP pre-coatings, due to hydrogen-bonding interaction between P4VP and poly(acrylic acid) (PAA). The long-term stability of these PMOXA-b-P4VP/PAA coatings showed that increasing PMOXA chain length can improve not only the hydrophilicity but also the stability of the coatings. This simple method can form stable coatings on either inorganic (such as, silicon wafer and coverslip) or organic material [such as, poly(methyl methacrylate) sheet] surface. At the same time, for the high-hydratability of PMOXA chains, these crosslinked coatings showed well protein-resistant and platelet/cell-repellent properties, and the antifouling properties and long-term availability were enhanced increasing PMOXA polymerization degree.


Block Copolymer Silicon Wafer Atom Transfer Radical Polymerization Atom Transfer Radical Polymerization Water Contact Angle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Special thanks to Prof. Longping Wen for kindly supplying us with human umbilical vein endothelial cells. This work was supported by the National Natural Science Foundation of China (Grant No. 21374109) and the Ministry of Science and Technology of China (Grant No. 2012CB933802).

Conflict of interest

The authors have declared no conflict of interest.

Supplementary material

10853_2015_9035_MOESM1_ESM.docx (1.1 mb)
Supplementary material 1 (DOCX 1092 kb)


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Lin Tan
    • 1
  • Longchao Bai
    • 1
  • Haikun Zhu
    • 1
  • Chong Zhang
    • 1
  • Lijuan Chen
    • 1
  • Yanmei Wang
    • 1
  • Hervé Cheradame
    • 2
  1. 1.CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiPeople’s Republic of China
  2. 2.Laboratoire LAMBE, UMR 8587, Université d’EvryEvry CedexFrance

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