Stable antifouling coatings by hydrogen-bonding interaction between poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) and poly(acrylic acid)
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Surface modified with so-called protein-repellent or antifouling polymers has become indispensable for the development of modern therapeutic and diagnostic medical devices. In this work, a series of novel well-defined poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) (PMOXA-b-P4VP) diblock copolymers were synthesized by using copper-catalyzed azide-alkyne cycloaddition reaction of α-alkynyl-PMOXA and ω-N3-P4VP, in which α-alkynyl-PMOXA and ω-N3-P4VP were prepared by cationic ring opening polymerization and atom transfer radical polymerization, respectively. Stable coatings were formed when dropping PAA solution on the top of PMOXA-b-P4VP pre-coatings, due to hydrogen-bonding interaction between P4VP and poly(acrylic acid) (PAA). The long-term stability of these PMOXA-b-P4VP/PAA coatings showed that increasing PMOXA chain length can improve not only the hydrophilicity but also the stability of the coatings. This simple method can form stable coatings on either inorganic (such as, silicon wafer and coverslip) or organic material [such as, poly(methyl methacrylate) sheet] surface. At the same time, for the high-hydratability of PMOXA chains, these crosslinked coatings showed well protein-resistant and platelet/cell-repellent properties, and the antifouling properties and long-term availability were enhanced increasing PMOXA polymerization degree.
KeywordsBlock Copolymer Silicon Wafer Atom Transfer Radical Polymerization Atom Transfer Radical Polymerization Water Contact Angle
Special thanks to Prof. Longping Wen for kindly supplying us with human umbilical vein endothelial cells. This work was supported by the National Natural Science Foundation of China (Grant No. 21374109) and the Ministry of Science and Technology of China (Grant No. 2012CB933802).
Conflict of interest
The authors have declared no conflict of interest.
- 5.Gudipati CS, Finlay JA, Callow JA, Callow ME, Wooley KL (2005) The antifouling and fouling-release perfomance of hyperbranched fluoropolymer (HBFP)-poly(ethylene glycol) (PEG) composite coatings evaluated by adsorption of biomacromolecules and the green fouling Alga Ulva. Langmuir 21:3044–3053CrossRefGoogle Scholar
- 11.Maechling-Strasser C, Déjardin P, Galin JC, Schmitt A, Housse-Ferrari V, Sébille B, Mulvihill JN, Cazenave JP (1989) Synthesis and adsorption of a poly(n-acetylethyleneimine)-polyethyleneoxide-poly(n-acetylethyleneimine) triblock-copolymer at a silica/solution interface: influence of its preadsorption on platelet adhesion and fibrinogen adsorption. J Biomed Mater Res 23:1395–1410CrossRefGoogle Scholar
- 20.Liu H, Shi RH, Wan WM, Yang RM, Wang YM (2008) A well-defined diblock copolymer of poly(ethylene oxide)-block-poly(4-vinylpyridine) for separation of basic proteins by capillary zone electrophoresis. Electrophoresis 29:2812–2819Google Scholar