Titanium oxide films appear to have extensive potentials in various applications largely because of its unique semiconducting properties. Usually, attentions are paid to characterize or tailor their surface electronic states, depending upon specific working circumstances as well as the requirements by their functional performances. Nevertheless, very rarely concern has been taken to the responsive effect on their electronic surface states when they come into contact with surrounding environments, which actually plays an important or even decisive role in their subsequent functions. For instance, cases like biomedical application could normally render the surface sequentially contacting with varying ambient media. In this study, we implemented initial contacting titanium oxide film with three representative bio-molecules (glucose, fucoidan, and heparin), and investigated the responsive effect of charge transfer doping on its electronic properties and its bio-performance. It was shown that the contacting imposed apparently n-type surface-charge-transfer-doping effect on the titanium oxide films. Their surface resistivity increased; their photo-luminance emissions were obviously quenched; their hydrophilic properties were improved; and denaturalization of fibrinogen on the surface was suppressed. Electrons were assigned to inject into titanium oxide film to produce the n-type doping effect. Our finding suggests that the semiconductor biomaterials surface properties and performances might be largely or even decisively influenced by the initial contacting of ambient conditions.
Contact Angle Surface Resistivity Titanium Oxide Film Space Charge Layer Flat Band Potential
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This work was financially supported by the National Natural Science Foundation of China (Nos. 20973134 and 20603027), the Sichuan Youth Science & Technology Foundation (No. 2012JQ0001) for Distinguished Young Scholars, and the Fundamental Research Funds for the Central Universities (No. SWJTU11ZT11).