Sustained release of ethyl cellulose micro-particulate drug delivery systems prepared using electrospraying
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Sustained-release ethyl cellulose (EC) micro-particles were prepared by electrospraying. Ketoprofen (KET) was taken as a model drug and various concentrations of EC functioned as a rate-controlling polymer. The morphology of the micro-particles was assessed using SEM. Images showed that as EC content increased, the granules shared similar surface characteristics containing pure EC. Micro-particle structures were analyzed by DSC, XRD, and FTIR. It was noted that the crystalline drug was converted into an amorphous form in all the granulations and that there was chemical interaction between KET and EC observed from FTIR. Dissolution studies revealed that as the amount of EC increased, the drug release rate decreased. This investigation suggests that electrospraying can be exploited as a useful tool for developing novel particulate drug delivery systems.
KeywordsDifferential Scanning Calorimetry Ketoprofen Physical Mixture Ethyl Cellulose Pure Drug
The authors would like to acknowledge the financial support from the UK-CHINA Joint Laboratory for Therapeutic Textiles and Biomedical Textile Materials “111 Project” from Ministry of Education of China (No. B07024).
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