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Sustained release of ethyl cellulose micro-particulate drug delivery systems prepared using electrospraying

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Abstract

Sustained-release ethyl cellulose (EC) micro-particles were prepared by electrospraying. Ketoprofen (KET) was taken as a model drug and various concentrations of EC functioned as a rate-controlling polymer. The morphology of the micro-particles was assessed using SEM. Images showed that as EC content increased, the granules shared similar surface characteristics containing pure EC. Micro-particle structures were analyzed by DSC, XRD, and FTIR. It was noted that the crystalline drug was converted into an amorphous form in all the granulations and that there was chemical interaction between KET and EC observed from FTIR. Dissolution studies revealed that as the amount of EC increased, the drug release rate decreased. This investigation suggests that electrospraying can be exploited as a useful tool for developing novel particulate drug delivery systems.

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References

  1. Soussan E, Cassel S, Blanzat M, Rico-Lattes I (2009) Chem Int Ed 48:274

    Article  CAS  Google Scholar 

  2. Wise DL (2000) Handbook of pharmaceutical controlled release technology. M. Dekker Inc., New York

    Google Scholar 

  3. Ramakrishna S, Fujihara K, Teo W, Lim T, Ma Z (2005) An introduction to electrospinning and nanofibers. World Scientific Publishing Co. Pvt. Ltd., Berlin

    Book  Google Scholar 

  4. Pareta R, Edirisinghe MJ (2006) J R Soc Interface 3:573

    Article  CAS  Google Scholar 

  5. Reyderman L, Stavchansky S (1995) Int J Pharm 124:75

    Article  CAS  Google Scholar 

  6. Xie J, Marijnissen JCM, Wang H (2006) Biomaterials 27:3321

    Article  CAS  Google Scholar 

  7. Xu Y, Hanna MA (2006) Int J Pharm 320:30

    Article  CAS  Google Scholar 

  8. Enayati M, Chang M-w, Bragman F, Edirisinghe M, Stride E (2011) Colloid Surf A 382:154

    Article  CAS  Google Scholar 

  9. Hayati I, Bailey AI, Tadros THF (1986) Nature 319:41

    Article  Google Scholar 

  10. Jaworek A (2007) Powder Technol 176:18

    Article  CAS  Google Scholar 

  11. Edirisinghe M, Jayasinghe S (2004) Int J Appl Ceram Technol 1:140

    Article  CAS  Google Scholar 

  12. Upadrashta SM, Katikaneni PR, Hileman GA, Keshary PR (1993) Drug Dev Ind Pharm 19:449

    Article  CAS  Google Scholar 

  13. Eichhorn SJ, Dufresne A, Aranguren M et al (2010) J Mater Sci 45:1. doi:10.1007/s10853-009-3874-0

    Article  CAS  Google Scholar 

  14. Wanga Z, Wub H, Liao C, Zhoud N, Cheng W, Wan Y (2011) Carbohydr Polym 84:624

    Article  Google Scholar 

  15. Vergote GJ, Vervaet C, Van Driessche I, Hoste S et al (2001) Int J Pharm 219:81

    Article  CAS  Google Scholar 

  16. Roda A, Sabatini L, Mirasoli M et al (2002) Int J Pharm 241:165

    Article  CAS  Google Scholar 

  17. Yamada T, Onishi H, Machida Y (2001) J Control Release 75:271

    Article  CAS  Google Scholar 

  18. Pignatello R, Ferro M, De Guidi G, Salemi G, Vandelli MA, Guccione S, Geppi M, Forte C, Puglisi G (2001) Int J Pharm 218:27

    Article  CAS  Google Scholar 

  19. Li B, Zhou H, Huang G (2007) J Mater Sci 42:199. doi:10.1007/s10853-006-1052-1

    Article  CAS  Google Scholar 

  20. Yu DG, Shen XX, Branford-White C, White K, Zhu LM, Bligh SWA (2009) Nanotechnology 20:055104

    Article  Google Scholar 

  21. Aouada FA, deMoura MR, Orts WJ, Mattoso LHC (2010) J Mater Sci 45:4977. doi:10.1007/s10853-009-4180-6

    Article  CAS  Google Scholar 

  22. Rao BS, Murthy KV (2002) Int J Pharm 231:97

    Article  CAS  Google Scholar 

  23. Makhija SN, Vavia PR (2002) Eur J Pharm Biopharm 54:9

    Article  CAS  Google Scholar 

  24. Agnihotri SA, Aminabhavi TM (2004) J Control Release 96:245

    Article  CAS  Google Scholar 

  25. Ravindra R, Rao AK, Khan AA (1999) J Appl Polym Sci 72:689

    Article  CAS  Google Scholar 

  26. Lambert JB, Shurvell HF, Lightner DA, Cooks RG (1998) Organic structural spectroscopy. Prentice Hall, Upper Saddle River

    Google Scholar 

  27. Silverstein RM, Bassler GC, Morril TC (1991) Spectrometric identification of organic compounds. Wiley, New York

    Google Scholar 

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Acknowledgements

The authors would like to acknowledge the financial support from the UK-CHINA Joint Laboratory for Therapeutic Textiles and Biomedical Textile Materials “111 Project” from Ministry of Education of China (No. B07024).

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People’s Republic of China

    Li-Ya Huang & Li-Min Zhu

  2. School of Material Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, People’s Republic of China

    Deng-Guang Yu

  3. Institute for Health Research and Policy, London Metropolitan University, London, N7 8DB, UK

    Christopher Branford-White

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  1. Li-Ya Huang
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  2. Deng-Guang Yu
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  3. Christopher Branford-White
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  4. Li-Min Zhu
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Correspondence to Li-Min Zhu.

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Huang, LY., Yu, DG., Branford-White, C. et al. Sustained release of ethyl cellulose micro-particulate drug delivery systems prepared using electrospraying. J Mater Sci 47, 1372–1377 (2012). https://doi.org/10.1007/s10853-011-5913-x

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  • DOI: https://doi.org/10.1007/s10853-011-5913-x

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