Abstract
Synthetic polymers were used to fabricate a three-dimensional (3D) porous scaffold of poly(propylene fumarate)/diethyl fumarate (PPF/DEF). PPF-based materials are good candidates for bone regeneration, because of their non-toxic, biodegradable byproducts, and excellent mechanical properties. However, they exhibit hydrophobic surface properties that have negative effects on cell adhesion. To change the surface properties of a PPF/DEF scaffold, the authors used three peptide modifications (RGD, cyclo RGD, and RGD-KRSR mixture) to the scaffold and tested the effects on MC3T3-E1 pre-osteoblast adhesion, proliferation, and differentiation. The results indicated that peptide modification (particularly the RGD-KRDR mixture) altered the hydrophobic surface properties of the PPF/DEF scaffold, and promoted cell adhesion. Thus, it was suggest that peptide modification is a useful method for changing the properties of the PPF/DEF scaffold surface and may be applicable in bone tissue engineering.
Similar content being viewed by others
References
Lan PX, Lee JW, Seol Y-J, Cho D-W (2009) J Mater Sci Mater Med 20(1):271
Hersel U, Dahmen C, Kessler H (2003) Biomaterials 24:4385
Chen Y, Mak AFT, Wang M, Li J, Wong MS (2006) Surface Coatings Technol 201:575
Tosatti S, Schwartz Z, Campbell C, Cochran DL, Vande Vondele S, Hubbell JA, Denzer A, Simson J, Wieland M, Lohmann CH, Textor M, Boyan BD (2005) J Biomed Mater Res A 68A(3):458
Domb AJ (1989) US Patent 4888413
Domb AJ, Kost J, Wiseman DM (1997) Handbook of biodegradable polymers. Harwood Academic Publishers, London
Frazier DD, Lathi VK, Gerhart TN, Hayers WC (1997) J Biomed Mater Res 35:383
Dettin Monica, Conconi MariaTeresa, Gambartto Roberta, Pasquato Antonella, Folin Marcella, Bello CarloDi, Parnigotto PierPaolo (2002) J Biomed Mater Res A 60(3):466
Lee JW, Ahn G, Kim DS, Cho D-W (2009) Microelec Eng 86:1465
Dee KC, Andersen TT, Bizios R (1998) J Biomed Mater Res 40(3):371
Kim TG, Park TG (2006) Tissue Eng Bio 12(2):221
Lee JW, Jung JH, Kim DS, Lim G, Cho D-W (2009) Microelelc Eng 86:1451
Lin Y-C, Brayfield CA, Gerlach JC, Rubin JP, Marra GK (2009) Acta Biomater 5:1416
Yoon JJ, Song SH, Lee DS, Park TG (2004) Biomaterials 25:5613
Acknowledgements
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (no. 2010-0018294), the Ministry of Education, Science Technology (MEST) and Korea Industrial Technology Foundation (KOTEF) through the Human Resource Training Project for Regional Innovation and WCU (World Class University) program through the Korea Science and Engineering Foundation funded by the Ministry of Education, science and Technology.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shin, J.H., Lee, J.W., Jung, J.H. et al. Evaluation of cell proliferation and differentiation on a poly(propylene fumarate) 3D scaffold treated with functional peptides. J Mater Sci 46, 5282–5287 (2011). https://doi.org/10.1007/s10853-011-5467-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10853-011-5467-y