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TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds

  • Syntactic and Composite Foams
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Abstract

TiO2 foam-like scaffolds with pore size ~300 μm and >95% porosity were fabricated by the foam replication method. A new approach to improve the structural integrity of the as-sintered foams, which exhibit extremely low compression strength, was explored by coating them with poly-(d,l-lactic acid) (PDLLA) or PDLLA/Bioglass® layers. The PDLLA coating was shown to improve the mechanical properties of the scaffold: the compressive strength was increased by a factor of ~7. The composite coating involving Bioglass® particles was shown to impart the rutile TiO2 scaffold with the necessary bioactivity for the intended applications in bone tissue engineering. A dense hydroxyapatite layer formed on the surface of the foams upon immersion in simulated body fluid for 1 week.

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Authors and Affiliations

  1. Department of Nanostructured Materials, J. Stefan Institute, 1000, Ljubljana, Slovenia

    Saša Novak

  2. Department of Materials, Imperial College London, Prince Consort Rd., London, SW7 2BP, UK

    John Druce, Qi-Zhi Chen & Aldo R. Boccaccini

Authors
  1. Saša Novak
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  2. John Druce
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  3. Qi-Zhi Chen
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  4. Aldo R. Boccaccini
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Correspondence to Aldo R. Boccaccini.

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Novak, S., Druce, J., Chen, QZ. et al. TiO2 foams with poly-(d,l-lactic acid) (PDLLA) and PDLLA/Bioglass® coatings for bone tissue engineering scaffolds. J Mater Sci 44, 1442–1448 (2009). https://doi.org/10.1007/s10853-008-2858-9

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  • DOI: https://doi.org/10.1007/s10853-008-2858-9

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