Journal of Materials Science

, Volume 42, Issue 13, pp 5147–5151 | Cite as

Characterization and application of magnetic P (St-co-MAA-co-AM)/SiO2 composite microspheres

  • Zuli Liu
  • Pandong Liu
  • Cuicui Liu
  • Kailun Yao
  • Qin Ning
  • Dong Xi
  • Huaping Xu


A sol–gel procedure was used to cover the magnetic P (St-co-MAA-co-AM) microspheres with a SiO2 layer, forming MMS/SiO2 composite micospheres. The composite spheres were synthesized by a two-step process. First, magnetic P (St-co-MAA-co-MA) microspheres (MMS) were prepared by microemulsion polymerization of styrene (St), methacrylic acid (MAA) and acryamide (AM) in the presence of magnetic fluid. In the next step, MMS/SiO2 spheres were obtained by addition of tetraethyl orthsilicate (TEOS) to the mixture of MMS, ammonium hydroxide and ethanol. The morphology, structure and properties of the MMS/SiO2 were characterized and the results indicate that the MMS/SiO2 spheres are about 2 μm in size with superparamagnetic behavior. The surface of the MMS/SiO2 spheres was functioned with –COOH successfully. Bioconjugation to IgG was also studied.


Ammonium Hydroxide Vibrate Sample Magnetometer Magnetic Fluid Methacrylic Acid Tetraethyl Orthosilicate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work is supported by the National Nature Science Foundation of China under Grant nos. 10574047 and 10574048 and Doctor Foundation of China (No. 20030487003). This work was also supported by the National 973 Project under Grant. No. 2006CB921606.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Zuli Liu
    • 1
    • 2
  • Pandong Liu
    • 1
  • Cuicui Liu
    • 1
  • Kailun Yao
    • 1
  • Qin Ning
    • 3
  • Dong Xi
    • 3
  • Huaping Xu
    • 4
  1. 1.Department of PhysicsHuazhong University of Science and TechnologyWuhanChina
  2. 2.State Key Laboratory of Coordination ChemistryNanjing UniversityNanjingChina
  3. 3.Tongji HospitalHuazhong University of Science and TechnologyWuhanChina
  4. 4.Sports CenterShanghai University of Traditional Chinese MedicineShanghaiChina

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